PREOPERATIVE ORAL DEXTROMETHORPHAN VERSUS CLONIDINE TO PREVENT TOURNIQUETINDUCED CARDIOVASCULAR RESPONSES IN ORTHOPEDIC PATIENTS UNDER GENERAL ANESTHESIA

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HONARMAND AZIM; SAFAVI MOHAMMAD REZA

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Paper Information

Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2007 | Volume:29 | Issue:58 Page(s): 35-45

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Title

PREOPERATIVE ORAL DEXTROMETHORPHAN VERSUS CLONIDINE TO PREVENT TOURNIQUETINDUCED CARDIOVASCULAR RESPONSES IN ORTHOPEDIC PATIENTS UNDER GENERAL ANESTHESIA

Author(s)

HONARMAND AZIM | SAFAVI MOHAMMAD REZA | Issue Writer Certificate

Keywords

CLONIDINEQ3

OEXTROMETHORPHANQ3

TOURNIQUETINFLATIONQ3

HYPERTENSIONQ3

Abstract

Background: Both preoperative oral dextromethorphan (OM) and IV CLONIDINE attenuates arterial blood pressure and heart rate increases during tourniquet inflation under general anesthesia. Effect of preoperative oral CLONIDINE on these variables was not investig clinically; it seems that CLONIDINE is more effective than OM in blunting of these responses.Materials and methods: We designed this study to compare the effect of preoperative oral OM or CLONIDINE on hemodynamic changes during tourniquet inflation in 75 patients undergoing lower limb surgery under general anesthesia. Patients were randomly assigned into three groups; OM (n=25; OM 30mg), CLONIDINE (n=25; CLONIDINE 3 mg/kg), and control (n=25; placebo) bgroups. Anesthesia was maintained with 1.2%-14% OM, CLONIDINE, or placebo was given orally in a double-blinded fashion ninety minutes before induction of anesthesia.Results: Systolic, diastolic, mean arterial blood pressure (SAP, OAP, MAP), and heart rate (HR) were measured at 0, 30, 45, 60 min after the start of tourniquet inflation, before tourniquet release (BTR), and 20 mins after tourniquet deflation. (20ATR). SAP, OAP and MAP were significantly lower in the CLONIDINE group compared with control after 45, 60 min tourniquet inflation and at BTR (p<0.05). Twenty minutes after deflation, OAP and MAP in the control group was still increased and significantly higher compared with the CLONIDINE group. Development of more than a 30% increase in systolic arterial pressure during tourniquet inflation was more frequent in the control group than the other groups.Conclusion: Preoperative oral CLONIDINE 3 mg/kg significantly prevented tourniquet-induced systemic arterial pressure in patients under general anesthesia better than oral DM.

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APA: Copy

HONARMAND, AZIM, & SAFAVI, MOHAMMAD REZA. (2007). PREOPERATIVE ORAL DEXTROMETHORPHAN VERSUS CLONIDINE TO PREVENT TOURNIQUETINDUCED CARDIOVASCULAR RESPONSES IN ORTHOPEDIC PATIENTS UNDER GENERAL ANESTHESIA. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 29(58), 35-45. SID. https://sid.ir/paper/63178/en

Vancouver: Copy

HONARMAND AZIM, SAFAVI MOHAMMAD REZA. PREOPERATIVE ORAL DEXTROMETHORPHAN VERSUS CLONIDINE TO PREVENT TOURNIQUETINDUCED CARDIOVASCULAR RESPONSES IN ORTHOPEDIC PATIENTS UNDER GENERAL ANESTHESIA. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2007;29(58):35-45. Available from: https://sid.ir/paper/63178/en

IEEE: Copy

AZIM HONARMAND, and MOHAMMAD REZA SAFAVI, “PREOPERATIVE ORAL DEXTROMETHORPHAN VERSUS CLONIDINE TO PREVENT TOURNIQUETINDUCED CARDIOVASCULAR RESPONSES IN ORTHOPEDIC PATIENTS UNDER GENERAL ANESTHESIA,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 29, no. 58, pp. 35–45, 2007, [Online]. Available: https://sid.ir/paper/63178/en

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