THE COMPARISON OF THE EFFECTS OF SILYBIN AND SILYBIN-PHOSPHATIDYLCHOLINE ON VIABILITY AND ESR EXPRESSION IN HUMAN BREAST CANCER T47D CELL LINE

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MAHMOODI NARGES; MOTAMED NASRIN; PAYLAKHI SEYED HASSAN

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Journal Paper

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Journal: Cell Journal (Yakhteh) Year:2014 | Volume:16 | Issue:3 (63) Page(s): 299-308

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Title

THE COMPARISON OF THE EFFECTS OF SILYBIN AND SILYBIN-PHOSPHATIDYLCHOLINE ON VIABILITY AND ESR EXPRESSION IN HUMAN BREAST CANCER T47D CELL LINE

Author(s)

MAHMOODI NARGES | MOTAMED NASRIN | PAYLAKHI SEYED HASSAN | Issue Writer Certificate

Keywords

SILYBIN

SILYBIN-PHOSPHATIDYLCHOLINE

BREAST CANCER

ESR1

Abstract

Objective: SILYBIN is a polyphenol with anti-oxidant and anti-cancer properties. The poor bioavailability of some polyphenols can be improved by binding to phosphatidylcholine. In recent years, studies have been conducted to evaluate the anti-cancer effect of SILYBIN.We studied the effect of SILYBIN and SILYBIN-phosphatidylcholine on ESR1 and ESR2 gene expression and viability in the T47D BREAST CANCER cell line.Materials and Methods: In this experimental study, a 3- (4, 5-Dimethylthiazol-2-Yl) -2, 5-Diphenyltetrazolium Bromide test (MTT test) was used to determine doses for cell treatment, and the gene expression was analyzed by real-time reverse transcriptase-polymerase chain reaction (real-time RT- PCR).Results: Significant dose- and time-dependent cell growth inhibitory effects of SILYBIN and SILYBIN-phosphatidylcholine along with ESR1 down-regulation were observed in T47D cells. In contrast toESR1, the T47D cell line showed negligible ESR2 expression.Conclusion: This study suggests that SILYBIN and SILYBIN-phosphatidylcholine down-regulate ESR1 in ER+breast cancers. Results also show that in the T47D cell line, SILYBINphosphatidylcholine has a much higher growth inhibitory effect and a more significant down-regulation of ESR1 compared with SILYBIN.

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APA: Copy

MAHMOODI, NARGES, MOTAMED, NASRIN, & PAYLAKHI, SEYED HASSAN. (2014). THE COMPARISON OF THE EFFECTS OF SILYBIN AND SILYBIN-PHOSPHATIDYLCHOLINE ON VIABILITY AND ESR EXPRESSION IN HUMAN BREAST CANCER T47D CELL LINE. CELL JOURNAL (YAKHTEH), 16(3 (63)), 299-308. SID. https://sid.ir/paper/633063/en

Vancouver: Copy

MAHMOODI NARGES, MOTAMED NASRIN, PAYLAKHI SEYED HASSAN. THE COMPARISON OF THE EFFECTS OF SILYBIN AND SILYBIN-PHOSPHATIDYLCHOLINE ON VIABILITY AND ESR EXPRESSION IN HUMAN BREAST CANCER T47D CELL LINE. CELL JOURNAL (YAKHTEH)[Internet]. 2014;16(3 (63)):299-308. Available from: https://sid.ir/paper/633063/en

IEEE: Copy

NARGES MAHMOODI, NASRIN MOTAMED, and SEYED HASSAN PAYLAKHI, “THE COMPARISON OF THE EFFECTS OF SILYBIN AND SILYBIN-PHOSPHATIDYLCHOLINE ON VIABILITY AND ESR EXPRESSION IN HUMAN BREAST CANCER T47D CELL LINE,” CELL JOURNAL (YAKHTEH), vol. 16, no. 3 (63), pp. 299–308, 2014, [Online]. Available: https://sid.ir/paper/633063/en

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