Evaluation of non steroidal anti inflammatory drugs toxicity on platelets in patients undergoing orthopedic surgeries

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PARISH MASOUD; FARZIN HALEH; Sakha Hanieh; Yahyavee Azita

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Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2017 | Volume:39 | Issue:4 (100) Page(s): 10-19

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Title

Evaluation of non steroidal anti inflammatory drugs toxicity on platelets in patients undergoing orthopedic surgeries

Author(s)

PARISH MASOUD | FARZIN HALEH | Sakha Hanieh | Yahyavee Azita | Issue Writer Certificate

Keywords

Nonsteroidal anti-inflammatory drugsQ1

ToxicityQ2

Orthopedic surgeryQ3

PlateletsQ2

Intraoperative bleedingQ2

Abstract

Introduction: Many patients undergo orthopedic surgeries due to trauma. Postoperative pain is high and severe and many Nonsteroidal anti-inflammatory drugs are used for analgesia other than opioids. But their use is limited for fear of drug induced complications especially anti platelet effects. The aim of this study was the evaluation of the non-steroidal anti-inflammatory drugs Toxicity on Platelets function on patients, undergoing orthopedic patients. Materials and methods: 370 patients were enrolled in this prospective descriptive cross-sectional study. The study group included 185 patients under treatment with non-Steroidal anti-inflammatory drugs, and the patients with no drug therapy were in control group, hematologic variables including hemoglobin, hematocrit, coagulation test, volume of bleeding and Platelets were recorded in tow groups. Results: In this study there was no significant difference between two groups in regard to age, sex, tobacco use, coagulation tests and hemorrhage during surgery. The high volume bleeding (control group) and number (study group) was seen. In study group the most aspirin use was noted. The Platelets were decreased postoperatively 6. 2%in study and 7. 33% in control group which the least was related to ketorolac and the maximum to naproxen. The postoperative hemoglobin, hematocrit and Platelet reduction was significant compared to the preoperative value. Conclusion: The results of this study showed that using low-dose non-steroidal anti-inflammatory drug in patients undergoing orthopedic surgeries has no toxic effect on Platelets and can be use safely.

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APA: Copy

PARISH, MASOUD, FARZIN, HALEH, Sakha, Hanieh, & Yahyavee, Azita. (2017). Evaluation of non steroidal anti inflammatory drugs toxicity on platelets in patients undergoing orthopedic surgeries. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 39(4 (100) ), 10-19. SID. https://sid.ir/paper/63345/en

Vancouver: Copy

PARISH MASOUD, FARZIN HALEH, Sakha Hanieh, Yahyavee Azita. Evaluation of non steroidal anti inflammatory drugs toxicity on platelets in patients undergoing orthopedic surgeries. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2017;39(4 (100) ):10-19. Available from: https://sid.ir/paper/63345/en

IEEE: Copy

MASOUD PARISH, HALEH FARZIN, Hanieh Sakha, and Azita Yahyavee, “Evaluation of non steroidal anti inflammatory drugs toxicity on platelets in patients undergoing orthopedic surgeries,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 39, no. 4 (100) , pp. 10–19, 2017, [Online]. Available: https://sid.ir/paper/63345/en

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