ASSESSING THE PROTECTIVE EFFECTS OF ZINC ON OXIDATIVE INJURY BIOMARKERS IN ACUTE MALATHION INDUCTION IN MALE RATS

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ABDOLMALEKI M.; GHASEMI H.; HEIDARISHAYESTEH T.; HOSSEINIZAIJOOD M.; RANJBAR A.

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Journal Paper

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Journal: Journal of Ilam University of Medical Sciences Year:2014 | Volume:22 | Issue:SUPPLEMENT Page(s): 147-152

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Title

ASSESSING THE PROTECTIVE EFFECTS OF ZINC ON OXIDATIVE INJURY BIOMARKERS IN ACUTE MALATHION INDUCTION IN MALE RATS

Author(s)

Keywords

MALATHION

ZINC

RAT

OXIDATIVE STRESS

Abstract

Introduction: MALATHION is one of the most common toxic organophosphorus insecticides (OPIs) which is normally used in the world. In addition to enzyme inhibition, cholinesterase also plays a role in the induction of OXIDATIVE STRESS and increased oxidants. On the other hand, zing is a crucial element that has antioxidant properties and protects against free radicals. The objective of this study was to investigate the possible protective effects of ZINC on organophosphate pesticide poisoning similar to MALATHION in male RATs. Materials & Methods: 20 male Male Wistar RATs weighing 250-180Grm were used in this study. The 20 male RATs were equally divided in to 4 groups (5 RATs each). Group I (control), while Group II was given malahion. Animals of Groups III received only ZINC. Group IV was given ZINC+ MALATHION once for acute test. After the treatment, blood was isolated. The animals were killed after 48 hours and cholinestrase activity (ChE) and OXIDATIVE STRESS marker such as total thiol groups (TTG) and total antioxidant capacity (TAC) concentration was measured. Data were then analyzed through SPSS software by One Way Anova analysis. The significance level was considered to be p<0.05. Findings: Results of data analysis showed that MALATHION significantly reduced the activity of ChE enzyme, TTG and TAC in blood in comparison to the control group. However, zing significantly increased the capacity of TTG and TAC in comparison to the MALATHION group.Discussion & Conclusion: Based on the above findings, it can be suggested that ZINC can reduce the oxidative damage of MALATHION by increasing free radicals and can be used in organophosphate pesticide poisoning such as MALATHION.

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APA: Copy

ABDOLMALEKI, M., GHASEMI, H., HEIDARISHAYESTEH, T., HOSSEINIZAIJOOD, M., & RANJBAR, A.. (2014). ASSESSING THE PROTECTIVE EFFECTS OF ZINC ON OXIDATIVE INJURY BIOMARKERS IN ACUTE MALATHION INDUCTION IN MALE RATS. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 22(SUPPLEMENT), 147-152. SID. https://sid.ir/paper/635562/en

Vancouver: Copy

ABDOLMALEKI M., GHASEMI H., HEIDARISHAYESTEH T., HOSSEINIZAIJOOD M., RANJBAR A.. ASSESSING THE PROTECTIVE EFFECTS OF ZINC ON OXIDATIVE INJURY BIOMARKERS IN ACUTE MALATHION INDUCTION IN MALE RATS. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;22(SUPPLEMENT):147-152. Available from: https://sid.ir/paper/635562/en

IEEE: Copy

M. ABDOLMALEKI, H. GHASEMI, T. HEIDARISHAYESTEH, M. HOSSEINIZAIJOOD, and A. RANJBAR, “ASSESSING THE PROTECTIVE EFFECTS OF ZINC ON OXIDATIVE INJURY BIOMARKERS IN ACUTE MALATHION INDUCTION IN MALE RATS,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. SUPPLEMENT, pp. 147–152, 2014, [Online]. Available: https://sid.ir/paper/635562/en

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