EFFECTS OF TOTAL EXTRACT AND ITS DIFFERENT HYDROMETHANOL FRACTIONS OF IRANIAN BLACK TEA ON INFLAMMATORY FACTORS AND GLYCOSILATED HEMOGLOBIN (HBA1C) IN STZ-INDUCED DIABETIC RATS

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ALIPOOR BEITOLLAH; ALIPOOR AGHIRI SARVAR; OSTADRAHIMI ALIREZA; DELAZAR ABBAS; MESGHARI MEHRAN

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Journal: Studies in Medical Sciences Year:2011 | Volume:21 | Issue:5 Page(s): 398-406

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Title

EFFECTS OF TOTAL EXTRACT AND ITS DIFFERENT HYDROMETHANOL FRACTIONS OF IRANIAN BLACK TEA ON INFLAMMATORY FACTORS AND GLYCOSILATED HEMOGLOBIN (HBA1C) IN STZ-INDUCED DIABETIC RATS

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Keywords

DIABETESQ2

RATQ3

TOTAL EXTRACT OF BLACK TEAQ3

INFLAMMATORY FACTORSQ3

GLYCOSILATED HEMOGLOBINQ3

Abstract

Background & Aims: Reliable findings indicate that INFLAMMATORY FACTORS and glycosilated hemoglubin (HbA1c) disorders has the main role in pathogeneses of DIABETES and its complications. Traditionally plant extracts have been used for DIABETES control. This study was aimed to examine the effect of total and different fractions of black tea on INFLAMMATORY FACTORS and GLYCOSILATED HEMOGLOBIN (HbA1c) in diabetic RATs.Materials and Methods: This study was conducted on 56 RATs which were randomly divided into 8 groups (7 RATs in each group) and they were studied for one month. The weight of RATs was 200–250 gr. Groups 1 and 2 were non-diabetic, groups 3–8 were diabetic, and DIABETES was induced by intraperitoneal injection of streptozotocin 60 mg/kg. Groups 1 to 8 were received by intraperitoneal injection: vehicle, total extract (50 mg/kgw), vehicle, total extrac (50 mg/kgw) t, methanol fractions of 20%, 40%, 60%, 80% plus 100% respectively. In the end of study blood samples were taken from all groups and GLYCOSILATED HEMOGLOBIN (HbA1c) and INFLAMMATORY FACTORS: Interleukin-1, 6, TNFa and CRP were measured.Results: In this study concluded that injection of total extract and 20% fraction of black tea had decreased INFLAMMATORY FACTORS in diabetic and non-diabetic RATs (p<0.05), but did not on GLYCOSILATED HEMOGLOBIN (HbA1c).Conclusion: It can be concluded that injection of total extract and 20% fraction of black tea had positive effect on INFLAMMATORY FACTORS in diabetic RATs.

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APA: Copy

ALIPOOR, BEITOLLAH, ALIPOOR AGHIRI, SARVAR, OSTADRAHIMI, ALIREZA, DELAZAR, ABBAS, & MESGHARI, MEHRAN. (2011). EFFECTS OF TOTAL EXTRACT AND ITS DIFFERENT HYDROMETHANOL FRACTIONS OF IRANIAN BLACK TEA ON INFLAMMATORY FACTORS AND GLYCOSILATED HEMOGLOBIN (HBA1C) IN STZ-INDUCED DIABETIC RATS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 21(5), 398-406. SID. https://sid.ir/paper/63600/en

Vancouver: Copy

ALIPOOR BEITOLLAH, ALIPOOR AGHIRI SARVAR, OSTADRAHIMI ALIREZA, DELAZAR ABBAS, MESGHARI MEHRAN. EFFECTS OF TOTAL EXTRACT AND ITS DIFFERENT HYDROMETHANOL FRACTIONS OF IRANIAN BLACK TEA ON INFLAMMATORY FACTORS AND GLYCOSILATED HEMOGLOBIN (HBA1C) IN STZ-INDUCED DIABETIC RATS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2011;21(5):398-406. Available from: https://sid.ir/paper/63600/en

IEEE: Copy

BEITOLLAH ALIPOOR, SARVAR ALIPOOR AGHIRI, ALIREZA OSTADRAHIMI, ABBAS DELAZAR, and MEHRAN MESGHARI, “EFFECTS OF TOTAL EXTRACT AND ITS DIFFERENT HYDROMETHANOL FRACTIONS OF IRANIAN BLACK TEA ON INFLAMMATORY FACTORS AND GLYCOSILATED HEMOGLOBIN (HBA1C) IN STZ-INDUCED DIABETIC RATS,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 21, no. 5, pp. 398–406, 2011, [Online]. Available: https://sid.ir/paper/63600/en

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