MANGANESE INTERFERENCE WITH IRON ABSORPTION BY EVERTEDGUT SAC

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HASANZADEH TAGHI

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Journal: Studies in Medical Sciences Year:2000 | Volume:11 | Issue:3 Page(s): 206-213

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Information Journal Paper

Title

MANGANESE INTERFERENCE WITH IRON ABSORPTION BY EVERTEDGUT SAC

Author(s)

HASANZADEH TAGHI | Issue Writer Certificate

Keywords

MANGANESEQ3

IRONQ3

INTESTINAL ABSORPTIONQ4

TRACE ELEMENTSQ4

Abstract

MANGANESE is an essential trace element which is taken part in the structure of some metaloenzymes. There is a little evidence for deficiency of MANGANESE in human, whereas its toxicity has been reported in several cases.There are a number of stages by which IRON metabolism being achieved. First stage is the uptake of IRON from lumen by intestinal mucosal cells. In mucosal cells the exact mechanism by which IRON transportation occurs is stilla matter of speculation.Previously, it has been reported that MANGANESE may inteifere with IRON metabolism either through INTESTINAL ABSORPTION or via blood transportation sites which might be due to chemical similarities between these metals.In this project the interrelationship between IRON (Fe) and MANGANESE (Mn) absorptions by rat everted gut sac (EGS) has been investigated. Incubation of freshly prepared EGS in Krebs ringer phosphate (KRP) medium PH 7.4 containing either Fe++ or Fe+++ showed that IRON absorption completed within 60 min of incubation time, whereas maximum MANGANESE absorption occurred after 30 min. The absorption of metal ions is a dose dependent process and maximum absorption carried out in the presence of 1.78 or 1.85 mM of IRON or MANGANESE respectively.Addition of IRON to reaction mixture reduced MANGANESE absorption significantly by 40% Identical level of MANGANESE decreased IRON absorption by approximately 15 percent. The effect of other factors on INTESTINAL ABSORPTION of IRON and MANGANESE have been investigated here.

Cites

INTERRELATION BTWEEN MANGANESE AND IRON METABOLISM IN RAT (IN VIVO STUDIES)

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APA: Copy

HASANZADEH, TAGHI. (2000). MANGANESE INTERFERENCE WITH IRON ABSORPTION BY EVERTEDGUT SAC. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 11(3), 206-213. SID. https://sid.ir/paper/64029/en

Vancouver: Copy

HASANZADEH TAGHI. MANGANESE INTERFERENCE WITH IRON ABSORPTION BY EVERTEDGUT SAC. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2000;11(3):206-213. Available from: https://sid.ir/paper/64029/en

IEEE: Copy

TAGHI HASANZADEH, “MANGANESE INTERFERENCE WITH IRON ABSORPTION BY EVERTEDGUT SAC,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 11, no. 3, pp. 206–213, 2000, [Online]. Available: https://sid.ir/paper/64029/en

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