STUDY OF THERAPEUTIC EFFECT OF PAROMOMYCIN SULFATE IN COMBINATION WITH GENTAMICIN SULFATE FILM FOR TREATMENT OF CUTANEOUS LEISHMANIASIS

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MOSTAGHIM M.; HEJAZI S.H.A.D.; TOLOUEI S.; ASILIAN A.; SADEGHIAN G.; SHATALEBI M.A.; FARIDZADEGAN H.

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Journal: Studies in Medical Sciences Year:2002 | Volume:13 | Issue:2 Page(s): 136-144

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Title

STUDY OF THERAPEUTIC EFFECT OF PAROMOMYCIN SULFATE IN COMBINATION WITH GENTAMICIN SULFATE FILM FOR TREATMENT OF CUTANEOUS LEISHMANIASIS

Author(s)

Keywords

LEISHMANIAQ3

GENTAMICIN SULFATEQ4

PAROMOMYCIN SULFATEQ4

SKINQ3

Abstract

Introduction: Cutaneous LEISHMANIAsis is one of the endemic disease in Iran and in this country Isfahan province is a hyperendemic region of the disease. The disease is distributed in many of townships and villages of north and eastern north of the city for the reason that the optimal treatment for cutaneous LEISHMANIAsis is unknown and response to therapy has been varied according to the species of LEISHMANIA and type of the used drugs the present study was designed. Method: Cure effects of a drug film with a base of ethylene cellulose and hydroxy propyl methyl cellulose (HPMC) contaning paromomycin 18% and gentamicin 0.5% was evaluated in 158 patients infected by cutaneous LEISHMANIAsis which their illness was proved by direct smear examination and culture. The study was a randomized single-blind placebo controlled. Each patient was under medical and lab examination in the treatment days, every 4 days for 28 days, and followed up at the days of 58 and 88 after the end of treatment. Results: Results of the study showed that utilization of this new physical form of the drug in a mentioned period of time caused significant cure effects in test group; so that 86% of cases in test group were cured at the end of the treatment but in placebo group only 13.3% of patients were cured dW1ngthis time (P<0.00001). Discussion: The new drug films were safe and were tolerated by patients. In general and because of good characters of the drug films they can be used as a suitable way for treatment of cutaneous LEISHMANIAsis. Revision of the production procedures in relation to the drug film bases and complementary expeJimentsfor improving the release of choice drug from the drug base was suggested.

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APA: Copy

MOSTAGHIM, M., HEJAZI, S.H.A.D., TOLOUEI, S., ASILIAN, A., SADEGHIAN, G., SHATALEBI, M.A., & FARIDZADEGAN, H.. (2002). STUDY OF THERAPEUTIC EFFECT OF PAROMOMYCIN SULFATE IN COMBINATION WITH GENTAMICIN SULFATE FILM FOR TREATMENT OF CUTANEOUS LEISHMANIASIS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 13(2), 136-144. SID. https://sid.ir/paper/64224/en

Vancouver: Copy

MOSTAGHIM M., HEJAZI S.H.A.D., TOLOUEI S., ASILIAN A., SADEGHIAN G., SHATALEBI M.A., FARIDZADEGAN H.. STUDY OF THERAPEUTIC EFFECT OF PAROMOMYCIN SULFATE IN COMBINATION WITH GENTAMICIN SULFATE FILM FOR TREATMENT OF CUTANEOUS LEISHMANIASIS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2002;13(2):136-144. Available from: https://sid.ir/paper/64224/en

IEEE: Copy

M. MOSTAGHIM, S.H.A.D. HEJAZI, S. TOLOUEI, A. ASILIAN, G. SADEGHIAN, M.A. SHATALEBI, and H. FARIDZADEGAN, “STUDY OF THERAPEUTIC EFFECT OF PAROMOMYCIN SULFATE IN COMBINATION WITH GENTAMICIN SULFATE FILM FOR TREATMENT OF CUTANEOUS LEISHMANIASIS,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 13, no. 2, pp. 136–144, 2002, [Online]. Available: https://sid.ir/paper/64224/en

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