INHIBITORY EFFECT OF NITRIC OXIDE IN PREVENTING PLASMA VITAMIN E REDUCTION DURING IRON DEXTRAN INJECTION IN MALE RATS

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SOUFIABADI M.; GOL A.; POURHEYDAR BAGHER; BABAZADEH H.

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Journal: Studies in Medical Sciences Year:2004 | Volume:15 | Issue:2 Page(s): 115-121

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Title

INHIBITORY EFFECT OF NITRIC OXIDE IN PREVENTING PLASMA VITAMIN E REDUCTION DURING IRON DEXTRAN INJECTION IN MALE RATS

Author(s)

SOUFIABADI M. | GOL A. | POURHEYDAR BAGHER | BABAZADEH H. | Issue Writer Certificate

Keywords

IRON DEXTRANQ4

NITRIC OXIDEQ3

OXIDATIVE STRESSQ2

VITAMIN EQ3

Abstract

Background & aim: While the role of iron in induction of OXIDATIVE STRESS has been confirmed, the NITRIC OXIDE one's (NO) remained vague. Also there have been some controversies on the interaction of iron and NO. In this study we have examined this interaction in plasma and we measured Vit E (Vitamin E) level as a marker of OXIDATIVE STRESS.Material & method: Sixty-four male rats were allocated into 8 groups as the following: 1- SHAM (Nonnal Saline), 2- Fe (IRON DEXTRAN), 3- ARG (L-Arginine - precursor of NO), 4- L-NAME (blocker of NO synthase, 5- Fe+ARG, 6- Fe+L-NAME, 7- DFO (Defferoxamine- Iron Shelator), and 8- ARG+DFO. After 20 hours of injections, Vit E in plasma was measured by using high peifonnance liquid chromatography.Results: Iron caused Vit E reduction in Fe group compared to SHAM group (p< 0.01). ARG did not have any effects on Vit E by itself. In Fe+ARG group there was no significant difference with sham group. The most reduction in Vit E occurred in group Fe+L-NAME so that its significant difference with SHAM and Fe+ARG was p<0.001 and 0.01 respectively.Discussion: We conclude that ARG by increasing NO concentration prevents and L-NAME by decreasing NO concentration exacerbates iron induced OXIDATIVE STRESS.

Cites

EXPERIMENTAL STUDIES ON THE EFFECTS OF NITRIC OXIDE ON THE PERCENTAGE PLATELET, RED BLOOD CELLS AND WHITE BLOOD CELLS OF GUINEA PIGS

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APA: Copy

SOUFIABADI, M., GOL, A., POURHEYDAR, BAGHER, & BABAZADEH, H.. (2004). INHIBITORY EFFECT OF NITRIC OXIDE IN PREVENTING PLASMA VITAMIN E REDUCTION DURING IRON DEXTRAN INJECTION IN MALE RATS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 15(2), 115-121. SID. https://sid.ir/paper/64266/en

Vancouver: Copy

SOUFIABADI M., GOL A., POURHEYDAR BAGHER, BABAZADEH H.. INHIBITORY EFFECT OF NITRIC OXIDE IN PREVENTING PLASMA VITAMIN E REDUCTION DURING IRON DEXTRAN INJECTION IN MALE RATS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2004;15(2):115-121. Available from: https://sid.ir/paper/64266/en

IEEE: Copy

M. SOUFIABADI, A. GOL, BAGHER POURHEYDAR, and H. BABAZADEH, “INHIBITORY EFFECT OF NITRIC OXIDE IN PREVENTING PLASMA VITAMIN E REDUCTION DURING IRON DEXTRAN INJECTION IN MALE RATS,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 15, no. 2, pp. 115–121, 2004, [Online]. Available: https://sid.ir/paper/64266/en

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