ASSOCIATION STUDY OF THE RS6062314 POLYMORPHISM IN THETNFRSF6B GENE IN MEN POPULATION WITH SPORADICMULTIPLE SCLEROSIS IN KHUZESTAN PROVINCE

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ZAIDALI SAMIRA; SAFINEJAD KYUMARS; GALEHDARI HAMID

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Journal: Studies in Medical Sciences Year:2017 | Volume:27 | Issue:10 Page(s): 856-862

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Title

ASSOCIATION STUDY OF THE RS6062314 POLYMORPHISM IN THETNFRSF6B GENE IN MEN POPULATION WITH SPORADICMULTIPLE SCLEROSIS IN KHUZESTAN PROVINCE

Author(s)

ZAIDALI SAMIRA | SAFINEJAD KYUMARS | GALEHDARI HAMID | Issue Writer Certificate

Keywords

MULTIPLE SCLEROSISQ2

RS6062314 POLYMORPHISMQ2

TNFRSF6B GENEQ1

KHUZESTANQ1

Abstract

Background & Aims: MULTIPLE SCLEROSIS (MS) is an autoimmune, demyelinating and neurodegenerative disease of the central nervous system (CNS). The pathogenesis of this disease is still unknown, although there are evidences of environmental factors affecting subjects with genetic predisposition factors.TNFRSF6B protein in human is coded by the TNFRSF6B GENE. One of the biological functions ofTNFRSF6B is that it acts as death decoy and prevents cell death under certain circumstances. Some examples of studies have shown that rs6062314 (tnfrsf6b) polymorphism is associated with risk of MS.The aim of this study was to investigate the association of RS6062314 POLYMORPHISM in TNFRSF6B GENE in men population with sporadic MULTIPLE SCLEROSIS in KHUZESTAN province.Materials & Methods: The type of study was case-control and 100 unrelated subjects including 50patients with low and moderate levels of MS (EDSS≤3) and 50 healthy men were enrolled and molecular techniques were used; in addition, extraction of DNA, PCR, and direct sequencing were studied.Results: The genotype and allele frequencies of rs6062314 (tnfrsf6b) between MS patients and controls did not differ significantly (P-value=0.268 and P CC=1.0 and OR=3.128, 95% CI=0.61-15.89 for C allele).Conclusion: Our results showed that there was no association between rs6062314 (tnfrsf6b) SNP polymorphism and MS disease.

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APA: Copy

ZAIDALI, SAMIRA, SAFINEJAD, KYUMARS, & GALEHDARI, HAMID. (2017). ASSOCIATION STUDY OF THE RS6062314 POLYMORPHISM IN THETNFRSF6B GENE IN MEN POPULATION WITH SPORADICMULTIPLE SCLEROSIS IN KHUZESTAN PROVINCE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 27(10), 856-862. SID. https://sid.ir/paper/64336/en

Vancouver: Copy

ZAIDALI SAMIRA, SAFINEJAD KYUMARS, GALEHDARI HAMID. ASSOCIATION STUDY OF THE RS6062314 POLYMORPHISM IN THETNFRSF6B GENE IN MEN POPULATION WITH SPORADICMULTIPLE SCLEROSIS IN KHUZESTAN PROVINCE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2017;27(10):856-862. Available from: https://sid.ir/paper/64336/en

IEEE: Copy

SAMIRA ZAIDALI, KYUMARS SAFINEJAD, and HAMID GALEHDARI, “ASSOCIATION STUDY OF THE RS6062314 POLYMORPHISM IN THETNFRSF6B GENE IN MEN POPULATION WITH SPORADICMULTIPLE SCLEROSIS IN KHUZESTAN PROVINCE,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 27, no. 10, pp. 856–862, 2017, [Online]. Available: https://sid.ir/paper/64336/en

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