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Title

REVERSAL EFFECT OF CORIANDRUM SATIVUM LEAVES EXTRACT ON LEARNING AND MEMORY DEFICITS INDUCED BY EPILEPSY IN MALE RAT

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Abstract

 Background: The extract of CORIANDRUM SATIVUM L., commonly known as coriander, belonging to the Apiaceae family (Umbelliferae), is cultivated throughout the world for its nutritional value. C. sativum was shown to enhance cognitive performance and recover MEMORY deficit. On the other hand, EPILEPSY induces cognitive disorders; learning and MEMORY deficits in different animal models. Thus, the present study was undertaken to investigate the effects of C. sativum on water MAZE LEARNING and MEMORY of epileptic rats.Materials and Methods: In this experimental study, C. sativum extract was injected intraperitoneally for 7 consecutive days to experimental animals. Pilocarpine was administered (i.p.) to induce epileptic convulsions. Morris water maze (MWM) apparatus served as the behavioral model for testing spatial learning and MEMORY. Latency to locate the platform, swimming distance and velocity were employed as variables in acquisition and probe trials, while crossing and proximity were only used in probe test.Results: The latency and distance to reach the hidden platform increased in pilocarpine treated rats. C. sativum extract decreased the latency and distance to platform compared with control and more prominently compared with epileptic group. Pilocarpine convulsions increased the platform location latency, but C. sativum extract did not reverse this seizure induced latency increase. Conversely, C. sativum extract reversed the seizure induced proximity increase.Conclusion: C. sativum extract may be a useful remedy in the management of EPILEPSY induced learning and MEMORY impairments.

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    APA: Copy

    ELAHDADI SALMANI, MAHMOUD, KHORSHIDI, MAHDI, & OZBAKI, JAMILE. (2015). REVERSAL EFFECT OF CORIANDRUM SATIVUM LEAVES EXTRACT ON LEARNING AND MEMORY DEFICITS INDUCED BY EPILEPSY IN MALE RAT. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 17(3), 0-0. SID. https://sid.ir/paper/666083/en

    Vancouver: Copy

    ELAHDADI SALMANI MAHMOUD, KHORSHIDI MAHDI, OZBAKI JAMILE. REVERSAL EFFECT OF CORIANDRUM SATIVUM LEAVES EXTRACT ON LEARNING AND MEMORY DEFICITS INDUCED BY EPILEPSY IN MALE RAT. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2015;17(3):0-0. Available from: https://sid.ir/paper/666083/en

    IEEE: Copy

    MAHMOUD ELAHDADI SALMANI, MAHDI KHORSHIDI, and JAMILE OZBAKI, “REVERSAL EFFECT OF CORIANDRUM SATIVUM LEAVES EXTRACT ON LEARNING AND MEMORY DEFICITS INDUCED BY EPILEPSY IN MALE RAT,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 17, no. 3, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/666083/en

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