The Potential Genotoxic Effects of Antineoplastic Drugs in Occupationally Exposed Nurses

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FAKHER HAIDY M.; METWALLY ESLAM S.; EL SHAFEY RABAB SH.

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Journal Paper

Paper Information

Journal: Asia Pacific Journal of Medical Toxicology Year:2020 | Volume:9 | Issue:2 Page(s): 60-66

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Information Journal Paper

Title

The Potential Genotoxic Effects of Antineoplastic Drugs in Occupationally Exposed Nurses

Author(s)

FAKHER HAIDY M. | METWALLY ESLAM S. | EL SHAFEY RABAB SH. | Issue Writer Certificate

Keywords

Antineoplastic

Oxidative stress

Comet assay

DNA damage

Abstract

Background: Antineoplastic drugs are commonly used globally. They directly interact with the tumor cell deoxyribonucleic acid and inhibit their growth. These actions are non-selective affecting both tumor cells and healthy cells producing toxic effects. The present study was designed to evaluate Oxidative stress and genotoxic effects of Antineoplastic drugs in occupationally exposed nurses under routine working conditions. Methods: The studied groups included 28 nurses working in Hematology and Oncology unit, Benha University Hospitals and 20 non exposed subjects that work in academic jobs in Benha Faculty of Medicine, matched in age, gender & socioeconomic status. Malondoaldehyde (MDA) & reduced glutathione (GSH) were measured for all participants as markers of Oxidative stress. Extent of DNA damage in leucocytes was also evaluated by Comet assay as a biomarker of genotoxicity. Results: There were a significant increase in MDA & reduction in GSH in occupationally exposed subjects than control. Also, extent of DNA damage in the lymphocytes of occupationally exposed participants has a high significance than the controls. The work duration and age had a significant impact on degree of DNA damage. Conclusion: occupationally exposed nurses to Antineoplastic agents are at greater risk of Oxidative stress with consequent DNA damage and potential genotoxic damage.

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APA: Copy

FAKHER, HAIDY M., METWALLY, ESLAM S., & EL SHAFEY, RABAB SH.. (2020). The Potential Genotoxic Effects of Antineoplastic Drugs in Occupationally Exposed Nurses. ASIA PACIFIC JOURNAL OF MEDICAL TOXICOLOGY (APJMT), 9(2), 60-66. SID. https://sid.ir/paper/666827/en

Vancouver: Copy

FAKHER HAIDY M., METWALLY ESLAM S., EL SHAFEY RABAB SH.. The Potential Genotoxic Effects of Antineoplastic Drugs in Occupationally Exposed Nurses. ASIA PACIFIC JOURNAL OF MEDICAL TOXICOLOGY (APJMT)[Internet]. 2020;9(2):60-66. Available from: https://sid.ir/paper/666827/en

IEEE: Copy

HAIDY M. FAKHER, ESLAM S. METWALLY, and RABAB SH. EL SHAFEY, “The Potential Genotoxic Effects of Antineoplastic Drugs in Occupationally Exposed Nurses,” ASIA PACIFIC JOURNAL OF MEDICAL TOXICOLOGY (APJMT), vol. 9, no. 2, pp. 60–66, 2020, [Online]. Available: https://sid.ir/paper/666827/en

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