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Information Journal Paper

Title

Prospects of Saffron and its Derivatives in Alzheimer's Disease

Pages

  233-252

Abstract

 Alzheimer’ s disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia in the old age population, making it a worldwide concern. Unfortunately, few drugs have been presented for treatment of mild and moderate AD. To meet this need, more effective anti-AD agents are emerging. Accumulating evidence supports the beneficial roles of natural-based products in brain function, neurotransmission, neurogenesis, synaptogenesis, and the prevention of amyloid fibrillation and neuronal injury. Several in vitro, preclinical, and clinical studies suggest that Saffron (its bioactive compounds) is a potential nutraceutical with antioxidant, radical scavenging, anti-inflammatory, hypolipidemic, hypotensive, neuroendocrine, and neuroprotective effects. It has also been proposed that Saffron may delay the onset of AD, prevent its progression or help to attenuate the symptoms of the disease. Therefore, we performed a comprehensive search on this plant and its derivatives for AD treatment. Saffron and its active constituents interfere with AD by improving learning behavior, spatial memory, and cognitive function; protecting against neuronal loss; inhibiting beta-amyloid aggregation and neurotoxicity; preventing senile plaques and neurofibrillary tangle (NFT) formation; suppressing the acetylcholinesterase (AChE) activity; and reducing neuroinflammation. Given conclusive scientific findings, Saffron and its derivatives might counter neurodegenerative diseases through multiple pathways. Further clinical trials are expected to confirm the neuroprotective properties of this herb and also to translate such findings to improve patients’ outcomes.

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    • Cite

    APA: Copy

    Zandi, Nadia, Pazoki, Benyamin, Momeni Roudsari, Nazanin, Lashgari, Naser Aldin, Jamshidi, Vahid, ABDOLGHAFFARI, AMIR HOSSEIN, & AKHONDZADEH, SHAHIN. (2021). Prospects of Saffron and its Derivatives in Alzheimer's Disease. ARCHIVES OF IRANIAN MEDICINE, 24(3), 233-252. SID. https://sid.ir/paper/673367/en

    Vancouver: Copy

    Zandi Nadia, Pazoki Benyamin, Momeni Roudsari Nazanin, Lashgari Naser Aldin, Jamshidi Vahid, ABDOLGHAFFARI AMIR HOSSEIN, AKHONDZADEH SHAHIN. Prospects of Saffron and its Derivatives in Alzheimer's Disease. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2021;24(3):233-252. Available from: https://sid.ir/paper/673367/en

    IEEE: Copy

    Nadia Zandi, Benyamin Pazoki, Nazanin Momeni Roudsari, Naser Aldin Lashgari, Vahid Jamshidi, AMIR HOSSEIN ABDOLGHAFFARI, and SHAHIN AKHONDZADEH, “Prospects of Saffron and its Derivatives in Alzheimer's Disease,” ARCHIVES OF IRANIAN MEDICINE, vol. 24, no. 3, pp. 233–252, 2021, [Online]. Available: https://sid.ir/paper/673367/en

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