VITAMIN C CAN ALTER LEAD-INDUCED PASSIVE AVOIDANCE LEARNING IMPAIRMENT IN RATS

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SALEHI IRAJ; SAHAB SOLEIMANI MARYAM; POURJAFAR MONA; GHASEMI MORAVEJ FAHIMEH; SOLEIMANI ASL SARA

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Journal: Anatomical Sciences Journal Year:2015 | Volume:12 | Issue:3 Page(s): 137-140

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Title

VITAMIN C CAN ALTER LEAD-INDUCED PASSIVE AVOIDANCE LEARNING IMPAIRMENT IN RATS

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Keywords

LEAD

VITAMIN C

PASSIVE AVOIDANCE LEARNING

RATS

Abstract

Introduction: LEAD (Pb) is a neurotoxin that its different effects on the central nervous system are well-known. Previous studies have reported the potent effects of VITAMIN C on memory. The present study was undertaken to evaluate the protective effects of VITAMIN C against LEADinduced amnesia.Methods: Male Wistar RATS were divided into 4 groups: the control (saline), negative control (LEAD), positive control (Vitamin C, 150 mg/kg), and experimental (LEAD+Vitamin C). To induce LEAD toxicity, the RATS received water containing 0.2% Pb instead of regular water for 1 month. PASSIVE AVOIDANCE LEARNING was assessed by Shuttle Box 2 months later. Retention was tested 24 hours after training.Results: The results showed that LEAD causes impairment in acquisition and retrieval processes of PASSIVE AVOIDANCE LEARNING and memory. However, VITAMIN C administration reinforced PASSIVE AVOIDANCE LEARNING and memory. All results were significant (P<0.001).Conclusion: VITAMIN C administration in RATS counteracts the negative effect of LEAD on spatial learning and memory.

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APA: Copy

SALEHI, IRAJ, SAHAB SOLEIMANI, MARYAM, POURJAFAR, MONA, GHASEMI MORAVEJ, FAHIMEH, & SOLEIMANI ASL, SARA. (2015). VITAMIN C CAN ALTER LEAD-INDUCED PASSIVE AVOIDANCE LEARNING IMPAIRMENT IN RATS. JOURNAL OF IRANIAN ANATOMICAL SCIENCES, 12(3), 137-140. SID. https://sid.ir/paper/677052/en

Vancouver: Copy

SALEHI IRAJ, SAHAB SOLEIMANI MARYAM, POURJAFAR MONA, GHASEMI MORAVEJ FAHIMEH, SOLEIMANI ASL SARA. VITAMIN C CAN ALTER LEAD-INDUCED PASSIVE AVOIDANCE LEARNING IMPAIRMENT IN RATS. JOURNAL OF IRANIAN ANATOMICAL SCIENCES[Internet]. 2015;12(3):137-140. Available from: https://sid.ir/paper/677052/en

IEEE: Copy

IRAJ SALEHI, MARYAM SAHAB SOLEIMANI, MONA POURJAFAR, FAHIMEH GHASEMI MORAVEJ, and SARA SOLEIMANI ASL, “VITAMIN C CAN ALTER LEAD-INDUCED PASSIVE AVOIDANCE LEARNING IMPAIRMENT IN RATS,” JOURNAL OF IRANIAN ANATOMICAL SCIENCES, vol. 12, no. 3, pp. 137–140, 2015, [Online]. Available: https://sid.ir/paper/677052/en

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