The effects of pre-treatment with olibanum and its constituent, boswellic acid on synaptic plasticity impairments induced by lipopolysaccharide in rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Marefati Narges; BEHESHTI FARIMAH; Memarpour Sara; REZAEI MOHAMMAD; HOSSEINI MAHMOUD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Avicenna Journal of Phytomedicine Year:2021 | Volume:11 | Issue:1 Page(s): 68-78

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

The effects of pre-treatment with olibanum and its constituent, boswellic acid on synaptic plasticity impairments induced by lipopolysaccharide in rats

Author(s)

Keywords

Olibanum

Boswellic acid

Lipopolysaccharide

Synaptic plasticity

Inflammation

Oxidative stress

Abstract

Objective: Olibanum (OLIB) and its component Boswellic acid (BOSA) are suggested to have anti-inflammatory, anti-oxidant and neuroprotective effects. In the present work, we examined effect of OLIB, and BOSA on the Synaptic plasticity impairment and Oxidative stress indicators in a rat model of neuro-Inflammation induced by Lipopolysaccharide (LPS). Materials and Methods: Forty rats were divided into the following four groups: (1) Control, (2) LPS, (3) OLIB (200 mg/kg), and (4) BOSA (10 mg/kg). The animals were pre-treated with OLIB extract, BOSA or the vehicle 30 min before LPS (1 mg/kg) administration, for 6 days. On the 6th day, electrophysiological recording was done. Long-term potentiation (LTP) from CA1 area of hippocampus was assessed. The animals were then sacrificed and their brains were removed for evaluation of the levels of interleukin-6 (IL-6), nitric oxide (NO) metabolites, malondialdehyde (MDA), thiol, superoxide dismutase (SOD) and catalase (CAT) in the cortex. Results: Administration of LPS decreased amplitude (p<0. 001) and slope (p<0. 01) of field excitatory postsynaptic potential (fEPSP). Pre-treatment enhanced these parameters (p<0. 05 to p<0. 001). LPS also increased cortical levels of IL-6 (P<0. 01), NO, and MDA (p<0. 001) while decreased thiol, SOD (p<0. 001), and CAT (p<0. 05). OLIB and BOSA diminished IL-6 (p<0. 05-p<0. 001), NO (p<0. 01-p<0. 001) and MDA level (p<0. 01 and p<0. 001, respectively) while improved SOD (p<0. 05 and p<0. 001, respectively), CAT (p<0. 05 and p<0. 001, respectively) and thiol content (p<0. 001). Conclusion: The results showed that OLIB and BOSA could improve Synaptic plasticity impairment induced by LPS as shown by a decrease in an Inflammation indicator along with the anti-oxidant effects.

Cites

No record.

References

Cite

APA: Copy

Marefati, Narges, BEHESHTI, FARIMAH, Memarpour, Sara, REZAEI, MOHAMMAD, & HOSSEINI, MAHMOUD. (2021). The effects of pre-treatment with olibanum and its constituent, boswellic acid on synaptic plasticity impairments induced by lipopolysaccharide in rats. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 11(1), 68-78. SID. https://sid.ir/paper/681816/en

Vancouver: Copy

Marefati Narges, BEHESHTI FARIMAH, Memarpour Sara, REZAEI MOHAMMAD, HOSSEINI MAHMOUD. The effects of pre-treatment with olibanum and its constituent, boswellic acid on synaptic plasticity impairments induced by lipopolysaccharide in rats. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2021;11(1):68-78. Available from: https://sid.ir/paper/681816/en

IEEE: Copy

Narges Marefati, FARIMAH BEHESHTI, Sara Memarpour, MOHAMMAD REZAEI, and MAHMOUD HOSSEINI, “The effects of pre-treatment with olibanum and its constituent, boswellic acid on synaptic plasticity impairments induced by lipopolysaccharide in rats,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 11, no. 1, pp. 68–78, 2021, [Online]. Available: https://sid.ir/paper/681816/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops