مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

294
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

177
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

EFFECT OF HELICOBACTER PYLORI ERADICATION ON INSULIN RESISTANCE AMONG PREDIABETIC PATIENTS: A PILOT STUDY AND SINGLE-BLIND RANDOMIZED CONTROLLED CLINICAL TRIAL

Pages

  0-0

Keywords

HELICOBACTER PYLORI (HP) INFECTION 

Abstract

 Background: Type II diabetes mellitus (T2DM) is the prevalent type of diabetes in the world. PREDIABETIC patients are the mostprobable group to get diabetes. Several studies have mentioned the role of inflammation in the incidence of diabetes. The originof inflammation can be infection such as Helicobacter pylori (HP) infection. This study was designed to explore the effect of HPeradication on INSULIN RESISTANCE. Materials and Methods: This single-blind randomized controlled clinical trial was conducted in2014-2015. The sample size consisted of 49 individuals who were in prediabetes stage with HP infection. Patients with positive stoolantigen were allocated randomly into two groups. The treatment group took medication to eradicate HP infection by the routinemethod of four-drug eradication. However, placebo capsules and tablets were given to the patients in the placebo group. Then fastingplasma glucose (FPG), fasting plasma insulin (FPI), and quantitative C-reactive protein (CRP) levels were measured and homeostaticmodel assessment of INSULIN RESISTANCE (HOMA-IR), homeostatic model assessment of beta-cell function (HOMA-B), Matsuda index, insulinogenic index, and disposition index were calculated.Results: Results of this study showed that FPI and HOMA-IR increasedsignificantly (P value of FPI=0.023 and P value of HOMA-IR=0.019) after HP eradication in the treatment group. On the otherhand, comparison of differences at the baseline and after 6 weeks in FPG (P value=0.045), FPI (P value=0.013), and HOMA-B (Pvalue=0.038) revealed significant differences between the placebo group and treatment group.Conclusion: Results showed thatHP eradication by a 2-week antibiotic medication did not decrease INSULIN RESISTANCE and even increased FPI and INSULIN RESISTANCEindices. So HP eradication among PREDIABETIC patients is not recommended for the decrease of INSULIN RESISTANCE and postponementof the development of diabetes mellitus.

Cites

References

  • No record.

    • Cite

    APA: Copy

    KACHOUEI, ALI, AMINI, MASOUD, SEBGHATOLAHI, VAHID, FEIZI, AWAT, HAMEDANI, POORIA, & IRAJ, BIJAN. (2016). EFFECT OF HELICOBACTER PYLORI ERADICATION ON INSULIN RESISTANCE AMONG PREDIABETIC PATIENTS: A PILOT STUDY AND SINGLE-BLIND RANDOMIZED CONTROLLED CLINICAL TRIAL. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 21(1), 0-0. SID. https://sid.ir/paper/682299/en

    Vancouver: Copy

    KACHOUEI ALI, AMINI MASOUD, SEBGHATOLAHI VAHID, FEIZI AWAT, HAMEDANI POORIA, IRAJ BIJAN. EFFECT OF HELICOBACTER PYLORI ERADICATION ON INSULIN RESISTANCE AMONG PREDIABETIC PATIENTS: A PILOT STUDY AND SINGLE-BLIND RANDOMIZED CONTROLLED CLINICAL TRIAL. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2016;21(1):0-0. Available from: https://sid.ir/paper/682299/en

    IEEE: Copy

    ALI KACHOUEI, MASOUD AMINI, VAHID SEBGHATOLAHI, AWAT FEIZI, POORIA HAMEDANI, and BIJAN IRAJ, “EFFECT OF HELICOBACTER PYLORI ERADICATION ON INSULIN RESISTANCE AMONG PREDIABETIC PATIENTS: A PILOT STUDY AND SINGLE-BLIND RANDOMIZED CONTROLLED CLINICAL TRIAL,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 21, no. 1, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/682299/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button