Evaluating Effects of Maternal Separation on Morphine-dependency and Spatial Learning and Memory of Rats

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HAMIDI GH.A.; SALAMI M.; TALAEI S.A.

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Journal: Internal Medicine Today Year:2018 | Volume:24 | Issue:4 Page(s): 263-269

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Information Journal Paper

Title

Evaluating Effects of Maternal Separation on Morphine-dependency and Spatial Learning and Memory of Rats

Author(s)

HAMIDI GH.A. | SALAMI M. | TALAEI S.A. | Issue Writer Certificate

Keywords

Maternal deprivationQ1

MorphineQ2

Maze learningQ2

Spatial memoryQ1

RatsQ2

Abstract

Aims: Facing maternal separation during early postnatal life leads to disturbances in the cognitive and neuro-chemical activities of the brain. The aim of this study was to investigate the effects of maternal separation on spatial learning and memory of Morphine-dependent Rats. Materials and Methods: This experimental study was carried out on 40 male Wistar Rats of 45 days old. Animals were divided into control group (CO), Morphine dependent (MD) and 3 group of Rats which maternally separated during 1 (MS1), 2 (MS2) and 3 weeks (MS3) after birth. Except CO Rats, the other groups were subcutaneously injected 10 mg/kg Morphine every 12 hours for 10 days. At the 11th day signs of withdrawal syndrome were evaluated and during next 4 consecutive days spatial learning was evaluated by Morris water maze (MWM). The Rats’ Spatial memory retrieval was also estimated at the last day. Findings: Although Morphine dependence did not affects spatial learning and memory of Rats, but 3 weeks maternal separation caused the animals spend more time and travel more distance to find the hidden platform than to CO group (P<0. 001 for both of comparisons). Also, they spent less time and passed less distance in the target quadrant in probe trial (P<0. 001 for both of comparisons). Conclusion: In conclusion, maternal separation impairs spatial learning and memory of Rats.

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APA: Copy

HAMIDI, GH.A., SALAMI, M., & TALAEI, S.A.. (2018). Evaluating Effects of Maternal Separation on Morphine-dependency and Spatial Learning and Memory of Rats. OFOGH-E-DANESH, 24(4 ), 263-269. SID. https://sid.ir/paper/68289/en

Vancouver: Copy

HAMIDI GH.A., SALAMI M., TALAEI S.A.. Evaluating Effects of Maternal Separation on Morphine-dependency and Spatial Learning and Memory of Rats. OFOGH-E-DANESH[Internet]. 2018;24(4 ):263-269. Available from: https://sid.ir/paper/68289/en

IEEE: Copy

GH.A. HAMIDI, M. SALAMI, and S.A. TALAEI, “Evaluating Effects of Maternal Separation on Morphine-dependency and Spatial Learning and Memory of Rats,” OFOGH-E-DANESH, vol. 24, no. 4 , pp. 263–269, 2018, [Online]. Available: https://sid.ir/paper/68289/en

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