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Information Journal Paper

Title

Glomerular Filtration Rate Estimation Based on Cystatin C Formulas among Neonates

Pages

  21-26

Abstract

 Background: Glomerular filtration rate (GFR) is the best indicator to assess renal function; however, it is difficult to perform it, especially in neonates. Serum creatinine is the most commonly used marker of GFR; nevertheless, it has some limitations since it can be affected by factors other than renal function. Cystatin C, another endogenous marker used to estimate GFR, is not affected by non-renal factors. The results of some studies suggest that serum cystatin C levels are more accurate tests of kidney function than serum creatinine levels. This study aimed to estimate GFR with cystatin C-based formulas among neonates and determine the correlations between these methods and the Schwartz formula. Methods: The population of this research consisted of 99 neonates whose serum creatinine and cystatin C levels were measured concurrently. Moreover, the glomerular filtration rate was estimated using the Schwartz formula and 14 cystatin C-based formulas separately. Results: Based on the findings, all GFR values based on cystatin C formulas correlated significantly with each other (P<0. 05); however, with one exception, none of these values correlated with Schwartz GFR (P>0. 05). The only cystatin C formula that yielded values correlating with the Schwartz formula was CysCrEq, which used serum cystatin C and creatinine concomitantly. Conclusion: It can be concluded that since all GFR values based on cystatin C correlated significantly and cystatin Cwasindependent of non-renal factors, cystatin C reflected the real GFR more accurately than serum creatinine. Nonetheless, further studies with gold standard techniques are required to verify the usefulness of cystatin C-based formulas.

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    APA: Copy

    KHALESI, NASRIN, Seirafianpour, Farnoosh, HOSEINI, ROZITA, OTUKESH, HASAN, RAHIMZADEH, NAHID, Nakhaie, Shahrbanoo, GOHARDEHI, GOLNAR, & Mohaghegh, Parisa. (2021). Glomerular Filtration Rate Estimation Based on Cystatin C Formulas among Neonates. IRANIAN JOURNAL OF NEONATOLOGY, 12(2), 21-26. SID. https://sid.ir/paper/683146/en

    Vancouver: Copy

    KHALESI NASRIN, Seirafianpour Farnoosh, HOSEINI ROZITA, OTUKESH HASAN, RAHIMZADEH NAHID, Nakhaie Shahrbanoo, GOHARDEHI GOLNAR, Mohaghegh Parisa. Glomerular Filtration Rate Estimation Based on Cystatin C Formulas among Neonates. IRANIAN JOURNAL OF NEONATOLOGY[Internet]. 2021;12(2):21-26. Available from: https://sid.ir/paper/683146/en

    IEEE: Copy

    NASRIN KHALESI, Farnoosh Seirafianpour, ROZITA HOSEINI, HASAN OTUKESH, NAHID RAHIMZADEH, Shahrbanoo Nakhaie, GOLNAR GOHARDEHI, and Parisa Mohaghegh, “Glomerular Filtration Rate Estimation Based on Cystatin C Formulas among Neonates,” IRANIAN JOURNAL OF NEONATOLOGY, vol. 12, no. 2, pp. 21–26, 2021, [Online]. Available: https://sid.ir/paper/683146/en

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