مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

85
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

75
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Protective effects of quercetin against hyperglycemia-induced oxidative stress in hepatic HepG2 cell line

Pages

  269-280

Abstract

 Objective: Hyperglycemia is a severe consequence of diabetes mellitus (DM). Throughinduction of Oxidative stress, it plays a major role in the pathogenesis of several complications in DM. Therefore, new strategies and antioxidants should be implemented inthe treatment of DM. Quercetin is a Flavonoid with strong antioxidant capacity found dominantly in vegetables, fruits, leaves, and grains. The current study aimed to investigate Quercetin protective effects under D-glucose-induced Oxidative stress by assessing antioxidant defense enzymes inHepG2 cells as an in vitro model. Materials and Methods: HepG2 cells were cultured with different concentrations of D-glucose (5. 5, 30 and 50 mM) and/or 25 μ M Quercetin for 48 and 72 hr, respectively. The effect of treatments on cellular integrity, Antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) activity, andcellular levels of glutathione (GSH) and malondialdehyde (MDA) wasdetermined. Results: D-glucose had various effects on intracellular antioxidant defense atdifferent doses and time-points and Quercetin could attenuate Oxidative stress and modulate antioxidant defenses. Conclusion: The results of this study indicated that Flavonoid Quercetin could be proposed as an agent protecting hepatic HepG2 cells against Oxidative stress associated with Hyperglycemia.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Yar Ahmadi, Amir, MORADI SARABI, MOSTAFA, SAYAHI, AHMAD, & ZAL, FATEMEH. (2021). Protective effects of quercetin against hyperglycemia-induced oxidative stress in hepatic HepG2 cell line. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 11(3), 269-280. SID. https://sid.ir/paper/687060/en

    Vancouver: Copy

    Yar Ahmadi Amir, MORADI SARABI MOSTAFA, SAYAHI AHMAD, ZAL FATEMEH. Protective effects of quercetin against hyperglycemia-induced oxidative stress in hepatic HepG2 cell line. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2021;11(3):269-280. Available from: https://sid.ir/paper/687060/en

    IEEE: Copy

    Amir Yar Ahmadi, MOSTAFA MORADI SARABI, AHMAD SAYAHI, and FATEMEH ZAL, “Protective effects of quercetin against hyperglycemia-induced oxidative stress in hepatic HepG2 cell line,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 11, no. 3, pp. 269–280, 2021, [Online]. Available: https://sid.ir/paper/687060/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button