COMPARATIVE EVALUATION OF THE EFFECTS OF TIO2 NANOPARTICLES AND ITS PHOTOCATALYSTIC FORM ON THE FORMATION OF FUNGAL BIOFILMS

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HAGHIGHI F.; ROUDBAR MOHAMMADI S.; MOHAMMADI P.; ESKANDARI M.

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Journal: Journal of Arak University Medical Sciences Year:2012 | Volume:15 | Issue:1 (60) Page(s): 27-34

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Title

COMPARATIVE EVALUATION OF THE EFFECTS OF TIO2 NANOPARTICLES AND ITS PHOTOCATALYSTIC FORM ON THE FORMATION OF FUNGAL BIOFILMS

Author(s)

HAGHIGHI F. | ROUDBAR MOHAMMADI S. | MOHAMMADI P. | ESKANDARI M. | Issue Writer Certificate

Keywords

CANDIDA ALBICANSQ2

FUNGAL BIOFILMSQ2

PHOTOCATALYSTQ2

TIO2 NANOPARTICLESQ2

Abstract

Background: CANDIDA ALBICANS is the fourth common cause of chronic fungal infections that cause both mucosal and deep tissue infections. Nowadays, mortality and morbidity due to C .albicans infections via medical devices, such as catheter and implants, are increasing. Therefore, finding new methods of combating such infectious agents seems necessary. In this study antifungal effects of titanium dioxide nanoparticles and PHOTOCATALYST TIO2 NANOPARTICLES on C .albicans biofilms were investigated.Materials and Methods: In this experimental study, TIO2 NANOPARTICLES were synthesized and exposed to UV ray with 370 nm wavelength. Biofilms of C. albicans were developed on flat-bottomed 96-well microtiter plates, and antifungal effects of TiO2 and PHOTOCATALYST TIO2 NANOPARTICLES were evaluated. Data were analyzed by t-test using SPSS software.Results: MIC50 of PHOTOCATALYST TIO2 NANOPARTICLES was 1.9 µg/ml and its MIC90 was 2.74 µg/ml while MFC was determined to be 3.37 µg/ml. Biofilms inhibitory concentration of TIO2 NANOPARTICLES, PHOTOCATALYST TIO2 NANOPARTICLES, and fluconazole for susceptible strains were 5.14, 4.54, and 4 µg/ml, respectively. These values for the fluconazole resistant strains were 5.35, 4.88, and 8 µg/ml, respectively.Conclusion: PHOTOCATALYST TIO2 NANOPARTICLES showed a suitable antifungal property against C. albicans biofilms compared with fluconazole. Thus it can be a new strategy in prevention of FUNGAL BIOFILMS, especially those formed on the surface of medical devices.

Cites

CORRELATION BETWEEN ERG11 GENE MUTATIONS AND FLUCONAZOLE RESISTANCE IN CANDIDA ALBICANS STRAINS ISOLATED FROM RASHT IN YEARS 2015-2016

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APA: Copy

HAGHIGHI, F., ROUDBAR MOHAMMADI, S., MOHAMMADI, P., & ESKANDARI, M.. (2012). COMPARATIVE EVALUATION OF THE EFFECTS OF TIO2 NANOPARTICLES AND ITS PHOTOCATALYSTIC FORM ON THE FORMATION OF FUNGAL BIOFILMS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 15(1 (60)), 27-34. SID. https://sid.ir/paper/68941/en

Vancouver: Copy

HAGHIGHI F., ROUDBAR MOHAMMADI S., MOHAMMADI P., ESKANDARI M.. COMPARATIVE EVALUATION OF THE EFFECTS OF TIO2 NANOPARTICLES AND ITS PHOTOCATALYSTIC FORM ON THE FORMATION OF FUNGAL BIOFILMS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2012;15(1 (60)):27-34. Available from: https://sid.ir/paper/68941/en

IEEE: Copy

F. HAGHIGHI, S. ROUDBAR MOHAMMADI, P. MOHAMMADI, and M. ESKANDARI, “COMPARATIVE EVALUATION OF THE EFFECTS OF TIO2 NANOPARTICLES AND ITS PHOTOCATALYSTIC FORM ON THE FORMATION OF FUNGAL BIOFILMS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 15, no. 1 (60), pp. 27–34, 2012, [Online]. Available: https://sid.ir/paper/68941/en

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