THE EFFECT OF DOCOSAHEXAENOIC ACID ON ANXIETY AND DEPRESSION BEHAVIORS IN ADULT MALE MICE

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ZAMANI NASTARAN; ESKANDARY AZADE

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2018 | Volume:20 | Issue:11 (128) Page(s): 47-55

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Title

THE EFFECT OF DOCOSAHEXAENOIC ACID ON ANXIETY AND DEPRESSION BEHAVIORS IN ADULT MALE MICE

Author(s)

ZAMANI NASTARAN | ESKANDARY AZADE | Issue Writer Certificate

Keywords

ANXIETYQ1

DEPRESSIONQ2

DOCOSAHEXAENOIC ACIDQ2

ELEVATED PLUS MAZEQ1

FORCED SWIMMING TESTQ1

Abstract

Background: ANXIETY and DEPRESSION are psychological and physiological states that are identified by physical, emotional and behavioral changes. According to studies conducted, there is evidence concerning the effect of DOCOSAHEXAENOIC ACID (DHA) on the emotional, motor, and cognitive functions of humans and animals. In this study, the effect of DHA (2.5 mg/kg) on ANXIETY and DEPRESSION behaviors in adult male mice was examined.Materials and Methods: In this experimental study, 42 adult male mice were randomly divided into 6 groups of 7 mice. The studied animals were divided into control, vehicle (intraperitoneal injection of sesame oil for 14 days) and treated groups (intraperitoneal injection of DHA with 2.5 mg/kg for 1, 3, 5, and 14 days) and then were studied for ANXIETY and DEPRESSION behaviors with ELEVATED PLUS MAZE and FORCED SWIMMING TESTs.Results: The results of this study showed that treatment of DOCOSAHEXAENOIC ACID did not have a significant effect on ANXIETY behaviors on days 1, 3, 5 (p>0.05), but 14-days treatment significantly reduced the duration of immobility time in the FORCED SWIMMING TEST (p˂ 0.05).Conclusion: According to the results, it can be said that DOCOSAHEXAENOIC ACID in the dose of 2.5 mg/kg does not affect the ANXIETY behaviors of rodents but it leads to a decrease in DEPRESSION behaviors.

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APA: Copy

ZAMANI, NASTARAN, & ESKANDARY, AZADE. (2018). THE EFFECT OF DOCOSAHEXAENOIC ACID ON ANXIETY AND DEPRESSION BEHAVIORS IN ADULT MALE MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 20(11 (128) ), 47-55. SID. https://sid.ir/paper/69081/en

Vancouver: Copy

ZAMANI NASTARAN, ESKANDARY AZADE. THE EFFECT OF DOCOSAHEXAENOIC ACID ON ANXIETY AND DEPRESSION BEHAVIORS IN ADULT MALE MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2018;20(11 (128) ):47-55. Available from: https://sid.ir/paper/69081/en

IEEE: Copy

NASTARAN ZAMANI, and AZADE ESKANDARY, “THE EFFECT OF DOCOSAHEXAENOIC ACID ON ANXIETY AND DEPRESSION BEHAVIORS IN ADULT MALE MICE,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 20, no. 11 (128) , pp. 47–55, 2018, [Online]. Available: https://sid.ir/paper/69081/en

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