Antioxidant and Hepatoprotective Effects of Irradiated Chicory Root on Liver Necrosis

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Salary Fatemeh; Ramzani Ghara Abdollah; Ezzati Ghadi Fereshteh; BAMDAD KOUROSH

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Journal: JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY Year:2020 | Volume:11 | Issue:2 Page(s): 0-0

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Title

Antioxidant and Hepatoprotective Effects of Irradiated Chicory Root on Liver Necrosis

Author(s)

Salary Fatemeh | Ramzani Ghara Abdollah | Ezzati Ghadi Fereshteh | BAMDAD KOUROSH | Issue Writer Certificate

Keywords

FTIR

Gamma Ray

Histology

Liver Necrosis

Abstract

Background: Gamma irradiation has been recognized as a reliable and safe method for improving the bio-components of plants. Objectives: This study aimed to evaluate the effect of irradiated chicory root extract on liver necrosis. Methods: Twenty-four adult male Wistar rats were divided equally into six treatment groups: Group I) Control, Group II) CCl4, Group III) CCl4 + irradiated chicory root extract, Group IV) CCl4 + chicory root extract, Group V) irradiated chicory root extract, and Group VI) chicory root extract. Animals were treated for four weeks. At the end of the study, catalase, SOD, lipid peroxidation, ALT, AST, histopathology, and Fourier Transform Infrared Spectroscopy (FTIR) were evaluated. Results: The results showed that the elevated levels of LPO, ALT, and AST in the CCl4 group decreased due to irradiated chicory and chicory root extract. Also, molecular changes and abnormalities in liver tissue improved due to irradiated chicory and chicory root extract. Moreover, the results showed that irradiated chicory roots were more effective than non-irradiated chicory. Conclusions: In conclusion, gamma-ray can increase the bioactive components of chicory root and is more effective in the scavenging of free radicals that cause liver necrosis in CCl4-treated rats.

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APA: Copy

Salary, Fatemeh, Ramzani Ghara, Abdollah, Ezzati Ghadi, Fereshteh, & BAMDAD, KOUROSH. (2020). Antioxidant and Hepatoprotective Effects of Irradiated Chicory Root on Liver Necrosis. JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH), 11(2), 0-0. SID. https://sid.ir/paper/691305/en

Vancouver: Copy

Salary Fatemeh, Ramzani Ghara Abdollah, Ezzati Ghadi Fereshteh, BAMDAD KOUROSH. Antioxidant and Hepatoprotective Effects of Irradiated Chicory Root on Liver Necrosis. JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH)[Internet]. 2020;11(2):0-0. Available from: https://sid.ir/paper/691305/en

IEEE: Copy

Fatemeh Salary, Abdollah Ramzani Ghara, Fereshteh Ezzati Ghadi, and KOUROSH BAMDAD, “Antioxidant and Hepatoprotective Effects of Irradiated Chicory Root on Liver Necrosis,” JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH), vol. 11, no. 2, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/691305/en

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