ASSOCIATION OF POLYMORPHISM OF LRP4 GENE (RS 4752947) AMONG POST MENOPAUSE WOMEN WITH OSTEOPOROSIS IN NORTH OF IRAN

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Kavoosian Saeid; ASGHARIAN ALIMOHAMMAD; Ataei Ramin

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2016 | Volume:19 | Issue:8 (113) Page(s): 79-87

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Title

ASSOCIATION OF POLYMORPHISM OF LRP4 GENE (RS 4752947) AMONG POST MENOPAUSE WOMEN WITH OSTEOPOROSIS IN NORTH OF IRAN

Author(s)

Kavoosian Saeid | ASGHARIAN ALIMOHAMMAD | Ataei Ramin | Issue Writer Certificate

Keywords

LRP4Q2

OSTEOPOROSISQ1

POLYMORPHISMQ1

Abstract

Background: OSTEOPOROSIS is describesd as a disorder and skeletal disease that decrease bonestrength and increases the risk of a bone fractures. Genetic factors have effect role in the progression of theosteoporosis. The aim of this study was to investigate the association between LRP4 gene POLYMORPHISM with OSTEOPOROSIS in a population of postmenopausal women from north of Iran.Materials and Methods: In this case-control study, 80 female patients with OSTEOPOROSIS and 80healthy females without OSTEOPOROSIS with average age of 45-60 has been investigated. After DNA extraction from genome samples, POLYMORPHISM of LRP4 (rs4752947) gene have been investigated by PCRRFLP method. Data were analyzed by SPSS software.Results: Our results showed no significant relationship between POLYMORPHISM ofLRP4 (rs4752947) gene and the risk of OSTEOPOROSIS disease in two patients and control groups. Also, ATgenotype and TT genotype compared with AA genotype increased the chance of disease by 1379 and 3.5, respectively. In addition, TT alleles compared with AA alleles, increased the chance of OSTEOPOROSIS up to1.605 times.Conclusion: Of course, more complementary studies considering other LRP4 gene subtypes withmore individuals for better findings are needed.

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References

OSTEOPOROSIS: A SILENT DISEASE WITH COMPLEX GENETIC CONTRIBUTION

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APA: Copy

Kavoosian, Saeid, ASGHARIAN, ALIMOHAMMAD, & Ataei, Ramin. (2016). ASSOCIATION OF POLYMORPHISM OF LRP4 GENE (RS 4752947) AMONG POST MENOPAUSE WOMEN WITH OSTEOPOROSIS IN NORTH OF IRAN. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 19(8 (113)), 79-87. SID. https://sid.ir/paper/69166/en

Vancouver: Copy

Kavoosian Saeid, ASGHARIAN ALIMOHAMMAD, Ataei Ramin. ASSOCIATION OF POLYMORPHISM OF LRP4 GENE (RS 4752947) AMONG POST MENOPAUSE WOMEN WITH OSTEOPOROSIS IN NORTH OF IRAN. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2016;19(8 (113)):79-87. Available from: https://sid.ir/paper/69166/en

IEEE: Copy

Saeid Kavoosian, ALIMOHAMMAD ASGHARIAN, and Ramin Ataei, “ASSOCIATION OF POLYMORPHISM OF LRP4 GENE (RS 4752947) AMONG POST MENOPAUSE WOMEN WITH OSTEOPOROSIS IN NORTH OF IRAN,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 19, no. 8 (113), pp. 79–87, 2016, [Online]. Available: https://sid.ir/paper/69166/en

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