Kiwifruit Supplementation Increases the Activity of the Paraoxonase Enzyme and decreases Oxidized Low-Density Lipoprotein in High-Fat Diet Fed Hamsters

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REZAEI NARJES; Zaherijamil Zahra; MORADKHANI SHIRIN; SAIDIJAM MASSOUD; KHODADADI IRAJ; ABBASI OSHAGHI EBRAHIM; TAVILANI HEIDAR

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Journal: Avicenna Journal of Medical Biochemistry Year:2020 | Volume:8 | Issue:2 Page(s): 58-63

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Title

Kiwifruit Supplementation Increases the Activity of the Paraoxonase Enzyme and decreases Oxidized Low-Density Lipoprotein in High-Fat Diet Fed Hamsters

Author(s)

Keywords

Kiwifruit

Paraoxonase 1

Liver tissue

High-density lipoprotein

High-fat diet

Abstract

Background: It is shown that Kiwifruit elevates serum High-density lipoprotein cholesterol (HDL-C) levels and exhibits beneficial effects on human health due to its antioxidant potential. Objectives: This study aimed to investigate the impact of Kiwifruit on the activity of the Paraoxonase 1 (PON1) enzyme, as a main antioxidant enzyme in HDL functionality, in a High-fat diet (HFD). Methods: To this end, 42 male Syrian hamsters were divided into 6 groups including hamsters receiving a normal diet (the control normal group), a regular diet supplemented with Kiwifruit at two concentrations (i. e., 1. 86 g/kg and 3. 73 g/kg), a HFD comprised of 15% butterfat + 0. 05% cholesterol (the control highfat group), and a HFD supplemented with Kiwifruit at two concentrations (i. e., 1. 86 and 3. 73 g/kg) for 8 weeks. Results: The results showed that supplementation of Kiwifruit to the HFD increased the levels of HDL-C and remarkably reduced the concentrations of oxidized low-density lipoprotein (ox-LDL) and malondialdehyde (MDA) compared with the control-HF group. In addition, the paraoxonase activity of PON1 significantly increased in HFD supplemented with Kiwifruit (1. 86 g/kg), and finally, arylesterase (ARE) activity increased in all treated groups when compared with untreated groups. Conclusion: Our findings suggested that Kiwifruit can improve the lipid profile and prevent oxidative stress-induced by lipid peroxidation in hamsters receiving HFD, thus increasing the ARE and paraoxonase activities of PON1.

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APA: Copy

REZAEI, NARJES, Zaherijamil, Zahra, MORADKHANI, SHIRIN, SAIDIJAM, MASSOUD, KHODADADI, IRAJ, ABBASI OSHAGHI, EBRAHIM, & TAVILANI, HEIDAR. (2020). Kiwifruit Supplementation Increases the Activity of the Paraoxonase Enzyme and decreases Oxidized Low-Density Lipoprotein in High-Fat Diet Fed Hamsters. AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, 8(2), 58-63. SID. https://sid.ir/paper/692153/en

Vancouver: Copy

REZAEI NARJES, Zaherijamil Zahra, MORADKHANI SHIRIN, SAIDIJAM MASSOUD, KHODADADI IRAJ, ABBASI OSHAGHI EBRAHIM, TAVILANI HEIDAR. Kiwifruit Supplementation Increases the Activity of the Paraoxonase Enzyme and decreases Oxidized Low-Density Lipoprotein in High-Fat Diet Fed Hamsters. AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY[Internet]. 2020;8(2):58-63. Available from: https://sid.ir/paper/692153/en

IEEE: Copy

NARJES REZAEI, Zahra Zaherijamil, SHIRIN MORADKHANI, MASSOUD SAIDIJAM, IRAJ KHODADADI, EBRAHIM ABBASI OSHAGHI, and HEIDAR TAVILANI, “Kiwifruit Supplementation Increases the Activity of the Paraoxonase Enzyme and decreases Oxidized Low-Density Lipoprotein in High-Fat Diet Fed Hamsters,” AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, vol. 8, no. 2, pp. 58–63, 2020, [Online]. Available: https://sid.ir/paper/692153/en

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