THE EFFECTS OF COENZYMEQ10 ON GENTAMICIN INDUCED NEPHROTOXICITY

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HAMEIDI ZAD ZEINAB; HAJIHASHEMI SAEED; RAHBARI ALI; GHANBARI FATEMEH

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Journal: Journal of Arak University Medical Sciences Year:2016 | Volume:19 | Issue:7 (112) Page(s): 22-35

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Title

THE EFFECTS OF COENZYMEQ10 ON GENTAMICIN INDUCED NEPHROTOXICITY

Author(s)

HAMEIDI ZAD ZEINAB | HAJIHASHEMI SAEED | RAHBARI ALI | GHANBARI FATEMEH | Issue Writer Certificate

Keywords

NEPHROTOXICITYQ3

GENTAMICINQ3

COENZYME Q10Q3

COBALAMINQ3

Abstract

Background: GENTAMICIN (GM) is one the aminoglycoside antibiotics which isroutinelyused to treatinfections gram-negative, either alone or insynergistic withbeta-lactamantibioticsused However, frequent useleads toserious side effectssuch asrenal toxicity, ototoxicity. Coenzyme Q10 has antioxidant, anti-inflammatory and vasodilatory properties. According to these properties of Coenzyme Q10 and tissue damage mechanism in GM induced-NEPHROTOXICITY, in this study, the effects of these two substances for the co-treatment and post -treatment on renal injury induced by GENTAMICIN were investigated.Materials and Methods: Experiments has been done on 77 male Wistar rats in weight range of 200 to 250 g. Animals were divided randomly into 5 groups of 7 numbers. Renal NEPHROTOXICITY induced by i.p injection of GENTAMICIN (100mg/kg) Therapeutic effect of coenzyme Q10 (10mg/kg)in the two protocols co-treatment and post-treatmentwas investigated.The animals after the last injectionon the ninth day of co-treatment andthe seventeenth day of post-treatmentwere placed into individual metabolic cages so as to collection urine and urine volume was measured gravimetrically. Afteranesthesia, systolic blood pressure and renal blood flow was measured. Then blood sampling was done. Amount of urea, creatinin, sodium, potassium and osmolarity was measured in plasma and urine samples. Left kidney, for doing histological experiments in 10% buffered formaldehyde and right kidney for biochemical experiments in fluid nitrogen was preserved.Results: Co-treatment with Coenzyme Q10 significantly decreased fractional excretion of sodium (6.37±1.33 %; p<0.001) and decreased fractional excretion of potassium (219.14±83.8%; p<0.001) MDA levels (2.13 ±0.24mmol/gkw; p<0.001), and significantly increased renal blood flow (6.38±0.1ml/min: p<0.01) and FRAP levels (24.44±0.42mmol/gkw; p<0.001). Post-treatment with coenzyme Q10 significantly decreased fractional excretion of sodium (3.58 ±0.57 %; p<0.001), potassium (111.77±29.4%; p<0.001) and MDA levels (3.08 ±0.12mmol/gkw; p<0.001) and significantly increased renal blood flow (6.74±0.15ml/min: p<0.001) and FRAP levels (24.34±0.75mmol/gkw; p<0.001) that is reduced by GENTAMICIN.Conclusion: According to the results, this study showed thatpost- treatment with coenzyme Q10 more protective effect on the kidney tissue andAnda greater increase inantioxidant defensecreated.

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APA: Copy

HAMEIDI ZAD, ZEINAB, HAJIHASHEMI, SAEED, RAHBARI, ALI, & GHANBARI, FATEMEH. (2016). THE EFFECTS OF COENZYMEQ₁₀ ON GENTAMICIN INDUCED NEPHROTOXICITY. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 19(7 (112)), 22-35. SID. https://sid.ir/paper/69272/en

Vancouver: Copy

HAMEIDI ZAD ZEINAB, HAJIHASHEMI SAEED, RAHBARI ALI, GHANBARI FATEMEH. THE EFFECTS OF COENZYMEQ₁₀ ON GENTAMICIN INDUCED NEPHROTOXICITY. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2016;19(7 (112)):22-35. Available from: https://sid.ir/paper/69272/en

IEEE: Copy

ZEINAB HAMEIDI ZAD, SAEED HAJIHASHEMI, ALI RAHBARI, and FATEMEH GHANBARI, “THE EFFECTS OF COENZYMEQ₁₀ ON GENTAMICIN INDUCED NEPHROTOXICITY,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 19, no. 7 (112), pp. 22–35, 2016, [Online]. Available: https://sid.ir/paper/69272/en

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