EVALUATION OF SERUM BIOCHEMICAL AND HISTOPATHOLOGICAL CHANGES IN MICE-DIABETIC KIDNEY FOLLOWED BY SIMULTANEOUS INJECTION OF NANOPARTICLES OF ZINC OXIDE AND THIAMINE

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KHAJE GANDOMANI AHMAD; Fatahian Dehkordi Rahmat Allah; HEIDARNEJAD MOHAMAD SAEED; JAFARIAN DEHKORDI MOHSEN

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Paper Information

Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2017 | Volume:20 | Issue:5 (122) Page(s): 103-118

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Title

EVALUATION OF SERUM BIOCHEMICAL AND HISTOPATHOLOGICAL CHANGES IN MICE-DIABETIC KIDNEY FOLLOWED BY SIMULTANEOUS INJECTION OF NANOPARTICLES OF ZINC OXIDE AND THIAMINE

Author(s)

KHAJE GANDOMANI AHMAD | Fatahian Dehkordi Rahmat Allah | HEIDARNEJAD MOHAMAD SAEED | JAFARIAN DEHKORDI MOHSEN | Issue Writer Certificate

Keywords

DIABETESQ1

KIDNEYQ1

MOUSEQ3

THIAMINEQ2

ZINC OXIDE NANOPARTICLESQ2

Abstract

Background: In this study, the effects of ZINC OXIDE NANOPARTICLES (ZnO NPs) and THIAMINE on the blood biochemical markers and KIDNEY histopathological changes after experimental DIABETES in mice was investigated.Materials and Methods: For this purpose, 56 mice were randomly divided into 8 groups of 7 each. Two groups of animals as controls (A) and THIAMINE (G) were considered. Other groups were diabetic by alloxan at a dose of 180 mg/kg. Group B mice were considered as diabetic group. To diabetic mice into Group C and D, ZnO NPs in concentrations of 0.1 and 0.5 mg/kg were intraperitoneally injected. Groups E and F; to these groups of diabetic mice, ZnO NPs in concentration of 0.1 and 0.5 mg/kg along with thiamin (30 mg/l) was injected. ZnO NPs in concentration of 0.1 was injected to group H mice. Changes in renal tissue along with some biochemical parameters were measured.Results: The results showed that DIABETES induced changes in some of the serum biochemical factors (GGT, BUN and creatinine) in rats (p<0.05). However, the administration of nanoparticles and THIAMINE reduced these negative effects. Exposure to DIABETES causes changes in the KIDNEY tissue of the MOUSE, in the disturbance of scaffolds for tissue integrity clutter, fragmentation of some convoluted tubules and congestion within the connective tissue.Conclusion: Treatment of the DIABETES mice by ZnO NPs and THIAMINE improves renal histopathologic structure and blood biochemistry levels.

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APA: Copy

KHAJE GANDOMANI, AHMAD, Fatahian Dehkordi, Rahmat Allah, HEIDARNEJAD, MOHAMAD SAEED, & JAFARIAN DEHKORDI, MOHSEN. (2017). EVALUATION OF SERUM BIOCHEMICAL AND HISTOPATHOLOGICAL CHANGES IN MICE-DIABETIC KIDNEY FOLLOWED BY SIMULTANEOUS INJECTION OF NANOPARTICLES OF ZINC OXIDE AND THIAMINE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 20(5 (122)), 103-118. SID. https://sid.ir/paper/69293/en

Vancouver: Copy

KHAJE GANDOMANI AHMAD, Fatahian Dehkordi Rahmat Allah, HEIDARNEJAD MOHAMAD SAEED, JAFARIAN DEHKORDI MOHSEN. EVALUATION OF SERUM BIOCHEMICAL AND HISTOPATHOLOGICAL CHANGES IN MICE-DIABETIC KIDNEY FOLLOWED BY SIMULTANEOUS INJECTION OF NANOPARTICLES OF ZINC OXIDE AND THIAMINE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2017;20(5 (122)):103-118. Available from: https://sid.ir/paper/69293/en

IEEE: Copy

AHMAD KHAJE GANDOMANI, Rahmat Allah Fatahian Dehkordi, MOHAMAD SAEED HEIDARNEJAD, and MOHSEN JAFARIAN DEHKORDI, “EVALUATION OF SERUM BIOCHEMICAL AND HISTOPATHOLOGICAL CHANGES IN MICE-DIABETIC KIDNEY FOLLOWED BY SIMULTANEOUS INJECTION OF NANOPARTICLES OF ZINC OXIDE AND THIAMINE,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 20, no. 5 (122), pp. 103–118, 2017, [Online]. Available: https://sid.ir/paper/69293/en

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