Effect of Eight Weeks of Resistance Training and Consumption of Tribulus Terrestris on Androgenic Receptor-1, Fas Ligand Gene Expression, and Lipid Profiles in Rats Exposed to Stanozolol

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Derakhshandeh Mohammad; TAGHIAN FARZANEH; JALALI DEHKORDI KHOSRO; HOSSEINI SEYED ALI

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Journal Paper

Paper Information

Journal: Avicenna Journal of Medical Biochemistry Year:2020 | Volume:8 | Issue:1 Page(s): 27-34

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Title

Effect of Eight Weeks of Resistance Training and Consumption of Tribulus Terrestris on Androgenic Receptor-1, Fas Ligand Gene Expression, and Lipid Profiles in Rats Exposed to Stanozolol

Author(s)

Derakhshandeh Mohammad | TAGHIAN FARZANEH | JALALI DEHKORDI KHOSRO | HOSSEINI SEYED ALI | Issue Writer Certificate

Keywords

Resistance training

Tribulus terrestris

Lipid profile

Androgen receptors

Stanozolol

Abstract

Background: Protective effect of medicinal plants on the heart has been reported, but the effect of Resistance training (RT) and Tribulus terrestris (TT) on the heart exposed to anabolic-androgenic steroids (AAS) abuse is still unknown. Objectives: The present study aimed to investigate the effect of RT and TT on androgen receptor-1 (ar-1), Fas ligand (fasl) gene expression and Lipid profiles in rats exposed to Stanozolol (S). Methods: Thirty-five male rats were selected and divided into 7 groups as follows: (1) sham (normal saline/Sh), (2) Stanozolol (S), (3) S+100 mg/kg TT (S+TT100), (4) S+ 50 mg/kg TT (S+TT50), (5) S+RT+TT, (6) S+RT+TT100, and (7) S+RT+TT50. Over a course of eight-week period, groups 3, 4, 6, and 7 received 50 and 100 mg/kg/d doses of TT peritoneally and groups 5-7 performed three sessions of increasing RT per week. Results: RT decreased plasma cholesterol and low-density lipoprotein cholesterol (LDL-C) levels, as well as ar-1 and fasl gene expression in S-exposed rats (P < 0. 05). TT50, TT100, SRTT100, and SRTT50 reduced ar-1 and fasl gene expressions (P < 0. 05). TT50 reduced triglyceride (TG), cholesterol and increased high-density lipoprotein-cholesterol (HDL-C) (P≤ 0. 01), and TT100 decreased LDL-C levels (P < 0. 05). Additionally, SRTT100 reduced TG, cholesterol, and LDL-C levels and increased HDL-C level (P < 0. 05), and SRTT50 decreased cholesterol level and increased HDL-C level in S-exposed rats (P < 0. 05). Conclusion: RT and consumption of TT appear to have protective effects on the improvement of apoptosisdependent androgen receptor-1 and Lipid profile in S-exposed rats.

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APA: Copy

Derakhshandeh, Mohammad, TAGHIAN, FARZANEH, JALALI DEHKORDI, KHOSRO, & HOSSEINI, SEYED ALI. (2020). Effect of Eight Weeks of Resistance Training and Consumption of Tribulus Terrestris on Androgenic Receptor-1, Fas Ligand Gene Expression, and Lipid Profiles in Rats Exposed to Stanozolol. AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, 8(1), 27-34. SID. https://sid.ir/paper/693873/en

Vancouver: Copy

Derakhshandeh Mohammad, TAGHIAN FARZANEH, JALALI DEHKORDI KHOSRO, HOSSEINI SEYED ALI. Effect of Eight Weeks of Resistance Training and Consumption of Tribulus Terrestris on Androgenic Receptor-1, Fas Ligand Gene Expression, and Lipid Profiles in Rats Exposed to Stanozolol. AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY[Internet]. 2020;8(1):27-34. Available from: https://sid.ir/paper/693873/en

IEEE: Copy

Mohammad Derakhshandeh, FARZANEH TAGHIAN, KHOSRO JALALI DEHKORDI, and SEYED ALI HOSSEINI, “Effect of Eight Weeks of Resistance Training and Consumption of Tribulus Terrestris on Androgenic Receptor-1, Fas Ligand Gene Expression, and Lipid Profiles in Rats Exposed to Stanozolol,” AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, vol. 8, no. 1, pp. 27–34, 2020, [Online]. Available: https://sid.ir/paper/693873/en

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