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Information Journal Paper

Title

Evaluation of Vitamin D-Binding Protein Gene Polymorphism and its Plasma Concentration in Kurdish Patients With Breast Cancer in Sanandaj, Iran

Pages

  89-93

Abstract

 Background: Several studies have indicated that Polymorphism in vitamin D pathway genes is associated with Breast cancer (BC) risk. Vitamin D-binding protein (VDBP) is a vital element in the metabolism of the vitamin D. VDBP carries the serum 25(OH) D3 to cells to promote vitamin D biological functions, such as cell proliferation and apoptosis. Missense SNP (rs. 7041) is a common Polymorphism in VDBP gene, which shows ethnic-specific allele frequencies. Objectives: This study presents the correlation of the rs7041 (Asp432Glu) gene Polymorphism and plasma concentrations of VDBP in Kurdish patients with BC in Sanandaj, Iran. Methods: This cross-sectional study included 44 premenopausal BC patients and 44 healthy subjects. Plasma VDBP concentration was measured by enzyme-linked immunosorbent assay (ELISA). The VDBP (rs7041) was genotyped by polymerase chain reaction– restriction fragment length Polymorphism (PCRRFLP). Results: VDBP level was associated with a non-significant risk of BC (P=0. 397). Frequencies of individuals with VDBP (rs7041) TT, TG, and GG genotypes were 13. 6%, 52. 2%, and 34. 09% in case group and 11. 3%, 79. 5%, and 9. 9% in control group, respectively. Genotype GG associated with increased susceptibility to developing BC (odds ratio [OR]=5. 172, CI: 1. 555-17. 2, P=0. 007). There was a significant reverse correlation between GT genotype and BC (OR=0. 282, 95% CI: 0. 110-0. 722, P=0. 008) Conclusion: The changes in the vitamin D pathway may increase susceptibility to develop BC in the Iranian Kurdish population.

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    Cite

    APA: Copy

    Moloudinia, Roya, Mahmoodi, Gelavij, ABDI, MOHAMMAD, AMINI, SABRIEH, & FERDOWSI, SHIRIN. (2020). Evaluation of Vitamin D-Binding Protein Gene Polymorphism and its Plasma Concentration in Kurdish Patients With Breast Cancer in Sanandaj, Iran. AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, 8(2), 89-93. SID. https://sid.ir/paper/693876/en

    Vancouver: Copy

    Moloudinia Roya, Mahmoodi Gelavij, ABDI MOHAMMAD, AMINI SABRIEH, FERDOWSI SHIRIN. Evaluation of Vitamin D-Binding Protein Gene Polymorphism and its Plasma Concentration in Kurdish Patients With Breast Cancer in Sanandaj, Iran. AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY[Internet]. 2020;8(2):89-93. Available from: https://sid.ir/paper/693876/en

    IEEE: Copy

    Roya Moloudinia, Gelavij Mahmoodi, MOHAMMAD ABDI, SABRIEH AMINI, and SHIRIN FERDOWSI, “Evaluation of Vitamin D-Binding Protein Gene Polymorphism and its Plasma Concentration in Kurdish Patients With Breast Cancer in Sanandaj, Iran,” AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, vol. 8, no. 2, pp. 89–93, 2020, [Online]. Available: https://sid.ir/paper/693876/en

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