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Information Journal Paper

Title

Seroepidemiological Study of Novel Coronavirus Disease (COVID-19) in Tehran, Iran

Pages

  121-128

Abstract

 Backgrounds: A novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now spread to all countries of the world, including Iran. Although anti-SARS-CoV-2 Antibodies may be identified in patients using immunological methods with sufficient sensitivity and specificity, the conclusive diagnosis of the disease is made using the molecular RT-PCR method. A populationbased seroepidemiological survey was conducted to quantify the proportion of the exposed population with SARS-CoV-2 Antibodies and evaluate whether the Antibodies are a marker of total or partial immunity compared to the population that remains susceptible to the virus. Material & Methods: This cross-sectional study was conducted to investigate the Seroprevalence of COVID-19 in Valiasr, Sajad, and Ghaem hospitals in Tehran, the capital of Iran, from April to the end of October 2020. Clotted and heparinized blood specimens (2mL) were collected from the patients. The serum and plasma were separated and stored at − 80  ° C until use. Anti-SARS-CoV-2 IgG and IgM Antibodies were examined in the serum samples of 1375 in-patients admitted to the hospitals using ELISA kits. The obtained data were analyzed using SPSS software Ver. 22. 0 by employing statistical tests such as Chi-square and Fisher’ s exact tests. A p-value <. 05 was considered as significant. Findings: In total, 1375 participants were enrolled in this study, and SARS-CoV-2 Antibodies were detected in 291 patients using IgM-IgG antibody assay. Among the seropositive patients studied, 187 were male (64. 3%), and 104 were female (35. 7%) (p<. 05). The mean age of the patients was 49± 8. 4 years; the majority of whom (27%) were in the age group of 3140 years. Also, the lowest frequency of infected cases was related to the age group of 1-10 years (p <. 05). The Seroprevalence of SARS-CoV-2 IgM or IgG Antibodies was determined to be 21. 2%. Diabetes mellitus was the most common underlying disease among SARS-CoV-2 patients [p=. 05; Odd Ratio=1. 61(0. 90-2. 91)]. Conclusion: The use of conventional serological assays, such as the enzyme-linked immunoassay (ELISA), for detecting specific IgM and IgG Antibodies in SARS-CoV-2 patients has a high-throughput advantage while minimizing false-negative results obtained using the RT-PCR method. In this study, the Seroprevalence of SARS-CoV-2 Antibodies was determined to be 21%. Control of diabetes, among other influential factors, plays an important role in the management and control of COVID-19.

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    Cite

    APA: Copy

    TABANEJAD, ZEINAB, Darvish, Sorena, Borjian Boroujeni, Zeinab, Asadi, Seyed Saeed, Mesri, Morteza, RAIESI, OMID, Getso, Muhammad Ibrahim, & ZAREEI, MAHDI. (2021). Seroepidemiological Study of Novel Coronavirus Disease (COVID-19) in Tehran, Iran. INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE), 7(2), 121-128. SID. https://sid.ir/paper/693888/en

    Vancouver: Copy

    TABANEJAD ZEINAB, Darvish Sorena, Borjian Boroujeni Zeinab, Asadi Seyed Saeed, Mesri Morteza, RAIESI OMID, Getso Muhammad Ibrahim, ZAREEI MAHDI. Seroepidemiological Study of Novel Coronavirus Disease (COVID-19) in Tehran, Iran. INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE)[Internet]. 2021;7(2):121-128. Available from: https://sid.ir/paper/693888/en

    IEEE: Copy

    ZEINAB TABANEJAD, Sorena Darvish, Zeinab Borjian Boroujeni, Seyed Saeed Asadi, Morteza Mesri, OMID RAIESI, Muhammad Ibrahim Getso, and MAHDI ZAREEI, “Seroepidemiological Study of Novel Coronavirus Disease (COVID-19) in Tehran, Iran,” INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE), vol. 7, no. 2, pp. 121–128, 2021, [Online]. Available: https://sid.ir/paper/693888/en

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