TOPICAL OLIVE LEAF EXTRACT IMPROVES HEALING OF ORAL MUCOSITIS IN GOLDEN HAMSTERS

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SHOWRAKI NAJMEH; MARDANI MARYAM; EMAMGHOREISHI MASOUMEH; ANDISHE TADBIR AZADEH; ARAM ALIREZA; MEHRIAR PEIMAN; OMIDI MAHMOUD; SEPEHRIMANESH MASOOD; KOOHI HOSSEINABADI OMID; TANIDEH NADER

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Journal: JOURNAL OF DENTISTRY Year:2016 | Volume:17 | Issue:4 Page(s): 334-342

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Title

TOPICAL OLIVE LEAF EXTRACT IMPROVES HEALING OF ORAL MUCOSITIS IN GOLDEN HAMSTERS

Author(s)

Keywords

5- FLUOROURACIL

ANTI-INFLAMMATORY

ANTIOXIDANT

OLIVE LEAF

ORAL MUCOSITIS

Abstract

Statement of the Problem: Oral mucositis (OM) is a common side effect of anticancer drugs and needs significant attention for its prevention.Purpose: This study aimed to evaluate the healing effects of olive leaf extract on 5-fluorouracil-induced OM in golden hamster.Materials and Method: OM was induced in 63 male golden hamsters by the combination of 5-fluorouracil injections (days 0, 5 and 10) and the abrasion of the cheek pouch (days 3 and 4). On day 12, hamsters were received topical olive leaf extract ointment, base of ointment, or no treatment (control) for 5 days. Histopathology evaluations, blood examinations, and tissue malondialdehyde level measurement were performed 1, 3 and 5 days after treatments.Results: Histopathology score and tissue malondialdehyde level were significantly lower in olive leaf extract treated group in comparison with control and base groups (p=0.000). Significant decreases in white blood cell, hemoglobin, hematocrit , and mean corpuscular volume and an increase in mean corpuscular hemoglobin concentration were observed in olive leaf extract treated group in comparison with control and base groups (p<0.05).Conclusion: Our findings demonstrated that daily application of olive leaf extract ointment had healing effect on 5-fluorouracil induced OM in hamsters. Moreover, the beneficial effect of olive leaf extract on OM might be due to its antioxidant and anti-inflammatory properties.

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APA: Copy

SHOWRAKI, NAJMEH, MARDANI, MARYAM, EMAMGHOREISHI, MASOUMEH, ANDISHE TADBIR, AZADEH, ARAM, ALIREZA, MEHRIAR, PEIMAN, OMIDI, MAHMOUD, SEPEHRIMANESH, MASOOD, KOOHI HOSSEINABADI, OMID, & TANIDEH, NADER. (2016). TOPICAL OLIVE LEAF EXTRACT IMPROVES HEALING OF ORAL MUCOSITIS IN GOLDEN HAMSTERS. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), 17(4), 334-342. SID. https://sid.ir/paper/694878/en

Vancouver: Copy

SHOWRAKI NAJMEH, MARDANI MARYAM, EMAMGHOREISHI MASOUMEH, ANDISHE TADBIR AZADEH, ARAM ALIREZA, MEHRIAR PEIMAN, OMIDI MAHMOUD, SEPEHRIMANESH MASOOD, KOOHI HOSSEINABADI OMID, TANIDEH NADER. TOPICAL OLIVE LEAF EXTRACT IMPROVES HEALING OF ORAL MUCOSITIS IN GOLDEN HAMSTERS. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2016;17(4):334-342. Available from: https://sid.ir/paper/694878/en

IEEE: Copy

NAJMEH SHOWRAKI, MARYAM MARDANI, MASOUMEH EMAMGHOREISHI, AZADEH ANDISHE TADBIR, ALIREZA ARAM, PEIMAN MEHRIAR, MAHMOUD OMIDI, MASOOD SEPEHRIMANESH, OMID KOOHI HOSSEINABADI, and NADER TANIDEH, “TOPICAL OLIVE LEAF EXTRACT IMPROVES HEALING OF ORAL MUCOSITIS IN GOLDEN HAMSTERS,” JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), vol. 17, no. 4, pp. 334–342, 2016, [Online]. Available: https://sid.ir/paper/694878/en

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