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Title

Non-Invasive Markers of Liver Fibrosis in Children with Chronic Hepatic Disorders

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  0-0

Abstract

 Background: The applicability of non-invasive markers for predicting hepatic fibrosis in the pediatric population with chronic liver abnormalities is unclear. Objectives: We investigated the applicability of common non-invasive liver fibrosis parameters for detecting liver fibrosis in children with chronic Hepatitis. Methods: This was a double-center study in Amir-Almomenin Hospital of Zabol and Namazi Hospital of Shiraz (2015-2017). Liver fibrosis was confirmed by Biopsy examination. AST to platelet ratio (APRI), AST to ALT ratio (AAR), and Fibrosis-4 (FIB-4) were evaluated. Results: Out of 47 patients, 23 (48. 9%) were females, and 24 (51. 1%) were males. The mean age was 9. 8 11. 3 months. APRI and FIB-4 correlated with fibrosis stages (r = 0. 1 and r = 0. 2, respectively). APRI showed an AUC of 0. 541 for detecting non-advanced fibrosis (stages 0, 1, and 2). AAR and FIB-4 represented AUCs of 0. 622 and 0. 592 for advanced fibrosis and cirrhosis, respectively. The highest sensitivity of APRI (70%) was obtained at the cut-off point of 0. 81 for cirrhosis. The highest specificities for APRI were observed at 0. 66 (68%) and 1. 37 (68%) for fibrotic stages 0 and 2, respectively. At the thresholds of 0. 71 and 0. 59, AAR rendered 78% sensitivity and 90% specificity for advanced fibrosis (stages 3 and 4) and no fibrosis (stage = 0), respectively. FIB-4 showed the highest sensitivity and specificity (70% and 60%) at the cut-off point of 0. 21 for detecting cirrhosis. Conclusions: APRI, FIB-4, and AAR can be regarded as useful markers in predicting fibrotic transformation in children with various etiologies of chronic Hepatitis.

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    APA: Copy

    SHAHRAMIAN, IRAJ, KHALILI, MANIJEH, SARGAZI, ALIREZA, Dechal, Alireza, Bazi, Mostafa, Jahantigh, Masoud, DELARAMNASAB, MOJTABA, & BAZI, ALI. (2020). Non-Invasive Markers of Liver Fibrosis in Children with Chronic Hepatic Disorders. GENE, CELL AND TISSUE, 7(3), 0-0. SID. https://sid.ir/paper/697018/en

    Vancouver: Copy

    SHAHRAMIAN IRAJ, KHALILI MANIJEH, SARGAZI ALIREZA, Dechal Alireza, Bazi Mostafa, Jahantigh Masoud, DELARAMNASAB MOJTABA, BAZI ALI. Non-Invasive Markers of Liver Fibrosis in Children with Chronic Hepatic Disorders. GENE, CELL AND TISSUE[Internet]. 2020;7(3):0-0. Available from: https://sid.ir/paper/697018/en

    IEEE: Copy

    IRAJ SHAHRAMIAN, MANIJEH KHALILI, ALIREZA SARGAZI, Alireza Dechal, Mostafa Bazi, Masoud Jahantigh, MOJTABA DELARAMNASAB, and ALI BAZI, “Non-Invasive Markers of Liver Fibrosis in Children with Chronic Hepatic Disorders,” GENE, CELL AND TISSUE, vol. 7, no. 3, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/697018/en

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