COMPARISON OF THYME COMBINATION REGIMEN WITH ROUTINE REGIMEN FOR ERADICATION OF HELICOBACTER PYLORI (HP) IN PEPTIC ULCER PATIENTS

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MOHAMMADALIZADEH A.H.; MAGHOOLZADEH A.R.

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2004 | Volume:7 | Issue:2 (27) Page(s): 39-47

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Title

COMPARISON OF THYME COMBINATION REGIMEN WITH ROUTINE REGIMEN FOR ERADICATION OF HELICOBACTER PYLORI (HP) IN PEPTIC ULCER PATIENTS

Author(s)

MOHAMMADALIZADEH A.H. | MAGHOOLZADEH A.R. | Issue Writer Certificate

Keywords

HELICOBACTERQ3

PEPTIC ULCERQ2

TREATMENTQ3

THYMEQ3

Abstract

Introduction: HP is the most common human infection which can result in gastritis, PEPTIC ULCER and gastric adenocarcinoma and lymphoma. Several combinations of drugs have been tested in HP eradication. THYME is a herbal drug that has antiseptic and GI anti spasmodic characteristics. In this study we tested THYME combination regimen in comparison with routine regimes.Materials and methods: This is a randomized clinical trial study. Ninethy patients with GI symptoms , confirmed PEPTIC ULCER and HP infection, were divided into three groups, group A (Omeperazole, Bismuth, Metronidazole and Tetracycline), group B: Omeperazole, Bismuth, Metronidazole, Tetracycline and THYME and group C: Bismuth, Omeperazole, Tetracycline and THYME. Duration of TREATMENT was 2 weeks .After TREATMENT they were given Ranitidine for 2 weeks and 2 weeks without any TREATMENT and then they were evaluated for HP and PEPTIC ULCER.Results: Distribution of sex, age, and smoking was equal in three groups. 81(90%) of cases had upper epigastric pain. Clinical recovery rate was 96.6% in group B and C which was more than group A (P=0.43). After TREATMENT endoscopy showed 70% complete relief in group C which was significantly more than two other groups(P=0.04). Complete response rate (negative RUT+negative HP histology) was 46.7% in group C (P=0.03).Conclusion: In general, group C regimen that substituted THYME with Metronidazole was more effective in HP eradication. With regard to high effectiveness, low complication and low cost of THYME, we suggest that adding this drug to routine quadriple HP eradication regimens could be useful.

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APA: Copy

MOHAMMADALIZADEH, A.H., & MAGHOOLZADEH, A.R.. (2004). COMPARISON OF THYME COMBINATION REGIMEN WITH ROUTINE REGIMEN FOR ERADICATION OF HELICOBACTER PYLORI (HP) IN PEPTIC ULCER PATIENTS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 7(2 (27)), 39-47. SID. https://sid.ir/paper/69748/en

Vancouver: Copy

MOHAMMADALIZADEH A.H., MAGHOOLZADEH A.R.. COMPARISON OF THYME COMBINATION REGIMEN WITH ROUTINE REGIMEN FOR ERADICATION OF HELICOBACTER PYLORI (HP) IN PEPTIC ULCER PATIENTS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2004;7(2 (27)):39-47. Available from: https://sid.ir/paper/69748/en

IEEE: Copy

A.H. MOHAMMADALIZADEH, and A.R. MAGHOOLZADEH, “COMPARISON OF THYME COMBINATION REGIMEN WITH ROUTINE REGIMEN FOR ERADICATION OF HELICOBACTER PYLORI (HP) IN PEPTIC ULCER PATIENTS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 7, no. 2 (27), pp. 39–47, 2004, [Online]. Available: https://sid.ir/paper/69748/en

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