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Information Journal Paper

Title

EFFECT OF REPEATED ELECTRICAL STIMULATION IN PENTYLENETETRAZOL-INDUCED KINDLING IN MALE RATS

Pages

  14-21

Abstract

 Introduction: KINDLING is an animal model of epilepsy induced by repeated stimulation of the brain‏. The amygdala has been the focus of interest, due in large part to its role in epilepsy induction and in FEAR CONDITIONING in both human and rats. The purpose of the present study was to evaluate whether low ELECTRICAL STIMULATION of foot pad of rats during fear can facilitate KINDLING susceptibility. Materials and Methods: In this experimental study 25 wistar male rats were trained for two way active avoidance learning in the shuttle box and on the basis of escape response were divided into fast and slow learning rats. Then each group was randomly assigned into two groups. ‏Test groups received conditional and unconditional stimulus and control groups received conditional stimulus for ten days. To induce KINDLING PENTYLENETETRAZOLe was administered to rats and seizure parameters were eveluated. Data were analyzed using one way ANOVA and Tukey's test. Results: Results demonstrated that slow learning rats in compare to fast learning ones were more prone to KINDLING. Repeated ELECTRICAL STIMULATION of slow learning rats during FEAR CONDITIONING facilitates KINDLING induction as compare to fast learning group. Conclusion: It seems that slow learning rats when exposed to repeated ELECTRICAL STIMULATION after FEAR CONDITIONING have more susceptibility to show seizure as compare to fast learning groups. It seems that neurons in the amygdala of slow learmhg rats have more pxitability.

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    APA: Copy

    PALIZVAN, M.R., KHADEMI, S., & GHAZNAVI, E.. (2005). EFFECT OF REPEATED ELECTRICAL STIMULATION IN PENTYLENETETRAZOL-INDUCED KINDLING IN MALE RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 8(1 (30)), 14-21. SID. https://sid.ir/paper/69814/en

    Vancouver: Copy

    PALIZVAN M.R., KHADEMI S., GHAZNAVI E.. EFFECT OF REPEATED ELECTRICAL STIMULATION IN PENTYLENETETRAZOL-INDUCED KINDLING IN MALE RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2005;8(1 (30)):14-21. Available from: https://sid.ir/paper/69814/en

    IEEE: Copy

    M.R. PALIZVAN, S. KHADEMI, and E. GHAZNAVI, “EFFECT OF REPEATED ELECTRICAL STIMULATION IN PENTYLENETETRAZOL-INDUCED KINDLING IN MALE RATS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 8, no. 1 (30), pp. 14–21, 2005, [Online]. Available: https://sid.ir/paper/69814/en

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