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Information Journal Paper

Title

The positive effect of short-term nano-curcumin therapy on insulin resistance and serum levels of afamin in patients with metabolic syndrome

Pages

  146-153

Abstract

 Objective: Metabolic syndrome (MS) is a cluster of cardio-metabolic risk factors. MS is known as a highly prevalent disease worldwide. According to the existing evidence, consuming curcumin has positive effects on lipids profile, glucose, and body weight. This study aimed to evaluate the effects of Nano-curcumin therapy on Insulin resistance and serum level of Afamin in patients with MS. Materials and Methods: Thirty MS patients (15 males and 15 females) received 80 mg/daily Nano-curcumin for two months. The samples of fasting blood were collected from the participants at the beginning and 60 days after initiation of the intervention to measure biomarkers. Results: Comparing pre-and post-treatment with Nano-curcumin values revealed a significant decrease in fasting plasma glucose (FPG) (p=0. 017), insulin, homeostatic model assessment of Insulin resistance (HOMA-IR) (p=0. 006), and Afamin (p=0. 047). Moreover, there was a significantly negative relationship between Afamin and high-density lipoprotein cholesterol (HDL-C) (p=0. 044), as well as a significantly positive relationship between Afamin and systolic (SBP) (p<0. 001) and diastolic (DBP) (p<0. 001) blood pressures. Conclusion: Results suggest that taking Nano-curcumin for 60 days may have positive effects on Afamin, FPG, insulin, and HOMA-IR in patients with MS, but would not significantly affect other metabolic profiles. More studies with larger sample sizes are required to confirm these findings.

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    APA: Copy

    KHEIRIPOUR, NEJAT, Khodamoradi, Zahra, RANJBAR, AKRAM, & BORZOUEI, SHIVA. (2021). The positive effect of short-term nano-curcumin therapy on insulin resistance and serum levels of afamin in patients with metabolic syndrome. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 11(2), 146-153. SID. https://sid.ir/paper/699826/en

    Vancouver: Copy

    KHEIRIPOUR NEJAT, Khodamoradi Zahra, RANJBAR AKRAM, BORZOUEI SHIVA. The positive effect of short-term nano-curcumin therapy on insulin resistance and serum levels of afamin in patients with metabolic syndrome. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2021;11(2):146-153. Available from: https://sid.ir/paper/699826/en

    IEEE: Copy

    NEJAT KHEIRIPOUR, Zahra Khodamoradi, AKRAM RANJBAR, and SHIVA BORZOUEI, “The positive effect of short-term nano-curcumin therapy on insulin resistance and serum levels of afamin in patients with metabolic syndrome,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 11, no. 2, pp. 146–153, 2021, [Online]. Available: https://sid.ir/paper/699826/en

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