مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

DEVELOPMENT OF 153SM/177LU-EDTMP AS A POSSIBLE THERAPEUTIC COMPLEX

Pages

  11-16

Abstract

 Introduction: Targeted radionuclide therapy (TRT) has been demonstrated to be an effective therapeutic tool in patients with disseminated bone metastasis. TRT is generally performed with a single radionuclide. In this study we investigated the feasibility of combined TRT with a high-energy beta emitter (153Sm) and a low energy beta emitter (177Lu) in wistar rats.Methods: The cocktail complex of 153Sm/177Lu-EDTMP was prepared. To determine the effect of metal-to-ligand (Me: EDTMP) molar ratio on labeling yield, several complex were analyzed after changing Me: EDTMP molar ratio from 1: 1 to 1: 50.153Sm/177Lu-EDTMP was administered intravenously through the tail vein of wistar rats. BIODISTRIBUTION data were collected at 2 hours to 7 day post injection and scintigraphic images were taken at 24 hours and 1, 2 week after administration of radiopharmaceutical.Results: The results revealed high skeletal uptake (3.5% and 3.4% ID/g at 24 hours post injection for 153Sm and 177Lu, respectively) with rapid blood clearance and minimal uptake in any of the major organs. Scintigraphic images verified high skeletal uptake.Conclusion: Our results indicate that the combination of 153Sm and 177Lu is feasible and safe. This study suggests that the combination of different radionuclides with different radiation energies and half-life, such as 153Sm and 177Lu, could be advantageous in patients with tumoral lesions of different sizes.

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    APA: Copy

    RANJBAR, HASSAN, BAHRAMI SAMANI, ALI, BEIKI, DAVOOD, & GHANNADI MARAGHEH, MOHAMMAD. (2017). DEVELOPMENT OF 153SM/177LU-EDTMP AS A POSSIBLE THERAPEUTIC COMPLEX. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 25(1 (SERIAL NUMBER 47)), 11-16. SID. https://sid.ir/paper/708468/en

    Vancouver: Copy

    RANJBAR HASSAN, BAHRAMI SAMANI ALI, BEIKI DAVOOD, GHANNADI MARAGHEH MOHAMMAD. DEVELOPMENT OF 153SM/177LU-EDTMP AS A POSSIBLE THERAPEUTIC COMPLEX. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2017;25(1 (SERIAL NUMBER 47)):11-16. Available from: https://sid.ir/paper/708468/en

    IEEE: Copy

    HASSAN RANJBAR, ALI BAHRAMI SAMANI, DAVOOD BEIKI, and MOHAMMAD GHANNADI MARAGHEH, “DEVELOPMENT OF 153SM/177LU-EDTMP AS A POSSIBLE THERAPEUTIC COMPLEX,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 25, no. 1 (SERIAL NUMBER 47), pp. 11–16, 2017, [Online]. Available: https://sid.ir/paper/708468/en

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