INTERACTIONS BETWEEN THE CANNABINOID AND NICOTINIC SYSTEMS IN INHIBITORY AVOIDANCE LEARNING IN MICE

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PIRI MORTEZA; NASEHI M.; ZARINDAST M.R.

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Paper Information

Journal: Journal of Rafsanjan University of Medical Sciences Year:2010 | Volume:9 | Issue:3 (36) Page(s): 162-174

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Title

INTERACTIONS BETWEEN THE CANNABINOID AND NICOTINIC SYSTEMS IN INHIBITORY AVOIDANCE LEARNING IN MICE

Author(s)

PIRI MORTEZA | NASEHI M. | ZARINDAST M.R. | Issue Writer Certificate

Keywords

WIN55Q3

212-2Q3

MECAMYLAMINEQ2

INHIBITORY AVOIDANCE LEARNINGQ2

MICEQ2

Abstract

Background and Objective: Cannabinoid exerts have widespread and complex effects on higher cognitive functions. An overlapping distribution of nicotinic receptors with cannabinoid receptors has been reported in some brain structures such as dorsal hippocampus, thus the functional interactions between cannabinoid and nicotinic systems in cognitive control seems possible. In the present study, the effects of MECAMYLAMINE on WIN55, 212-2 induced state-dependent learning was examined.Materials and Methods: In this experimental study, 280 adult male NMRI MICE were anaesthetized and, then, were cannulae implanted bilaterally in the CA1 regions of the dorsal hippocampus using stereotaxic method. Seven days after the recovery from surgery, behavioral testing was started in inhibitory avoidance task. The animals were trained in a step- down type inhibitory avoidance task and tested 24h after training to measure the step- down latency for the assessment of memory retention. All experiments were conducted in accordance with "standard ethical guidelines for animal care and use". Results: Post-training administration of WIN55, 212-2 and AM251 decreased the memory retrieval. The memory impairment induced by WIN55, 212-2 was completely reversed by pre-test administration of WIN55, 212-2 and/or MECAMYLAMINE, suggesting WIN55, 212-2 induced state-dependent memory. Conclusion: These results suggest that nicotinic receptors of the dorsal hippocampal may play an important role in WIN55, 212-2-induced amnesia and WIN55, 212-2 state-dependent memory.

Cites

THE EFFECT OF D2 RECEPTOR AGONIST INJECTION IN THE NUCLEUS ACCUMBENS ON RESTORATION OF MORPHINE INDUCED AMNESIA BY NICOTINE IN MALE RATS

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APA: Copy

PIRI, MORTEZA, NASEHI, M., & ZARINDAST, M.R.. (2010). INTERACTIONS BETWEEN THE CANNABINOID AND NICOTINIC SYSTEMS IN INHIBITORY AVOIDANCE LEARNING IN MICE. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 9(3 (36)), 162-174. SID. https://sid.ir/paper/70964/en

Vancouver: Copy

PIRI MORTEZA, NASEHI M., ZARINDAST M.R.. INTERACTIONS BETWEEN THE CANNABINOID AND NICOTINIC SYSTEMS IN INHIBITORY AVOIDANCE LEARNING IN MICE. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2010;9(3 (36)):162-174. Available from: https://sid.ir/paper/70964/en

IEEE: Copy

MORTEZA PIRI, M. NASEHI, and M.R. ZARINDAST, “INTERACTIONS BETWEEN THE CANNABINOID AND NICOTINIC SYSTEMS IN INHIBITORY AVOIDANCE LEARNING IN MICE,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 9, no. 3 (36), pp. 162–174, 2010, [Online]. Available: https://sid.ir/paper/70964/en

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