THE DIAGNOSTIC DIFFERENCE BETWEEN 18F- FDG PET AND 99MTC-HMPAO SPECT PERFUSION IMAGING IN ASSESSMENT OF ALZHEIMER'S DISEASE

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GALIL HAMED MAGED ABDEL; ABDEL GHANY AHMED FATHY

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Journal Paper

Paper Information

Journal: Iranian Journal of Nuclear Medicine Year:2017 | Volume:25 | Issue:1 (SERIAL NUMBER 47) Page(s): 17-22

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Title

THE DIAGNOSTIC DIFFERENCE BETWEEN 18F- FDG PET AND 99MTC-HMPAO SPECT PERFUSION IMAGING IN ASSESSMENT OF ALZHEIMER'S DISEASE

Author(s)

GALIL HAMED MAGED ABDEL | ABDEL GHANY AHMED FATHY | Issue Writer Certificate

Keywords

PET

SPECT

HMPAO

ALZHEIMER'S DISEASE

Abstract

Introduction: Brain imaging with F-18 fluorodeoxyglucose (18F-FDG) positron emission tomography or Tc-99m hexamethylpropyleneamine oxime (99mTc-HMPAO) SPECT is widely used for the evaluation of Alzheimer's dementia (AD); we aim to assess superiority of one method over the other.Methods: Twenty four patients with clinical diagnosis of Alzheimer disease underwent 18F-FDG PET and 99mTc-HMPAO SPECT in order to assess the zones of hypo metabolism & hypoperfusion specific for ALZHEIMER'S DISEASE.Results: 18F-FDG PET showed specific zones of hypometabolism in 19 patients (79.1%) while SPECT was positive in 15 cases (62.5%) with statistically significant difference (P=0.027).Conclusion: 18F-FDG PET was significantly superior to HMPAO SPECT and 18F-FDG PET could replace the classic role of perfusion SPECT in diagnosis of ALZHEIMER'S DISEASE.

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APA: Copy

GALIL HAMED, MAGED ABDEL, & ABDEL GHANY, AHMED FATHY. (2017). THE DIAGNOSTIC DIFFERENCE BETWEEN ¹⁸F- FDG PET AND ^99MTC-HMPAO SPECT PERFUSION IMAGING IN ASSESSMENT OF ALZHEIMER'S DISEASE. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 25(1 (SERIAL NUMBER 47)), 17-22. SID. https://sid.ir/paper/715186/en

Vancouver: Copy

GALIL HAMED MAGED ABDEL, ABDEL GHANY AHMED FATHY. THE DIAGNOSTIC DIFFERENCE BETWEEN ¹⁸F- FDG PET AND ^99MTC-HMPAO SPECT PERFUSION IMAGING IN ASSESSMENT OF ALZHEIMER'S DISEASE. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2017;25(1 (SERIAL NUMBER 47)):17-22. Available from: https://sid.ir/paper/715186/en

IEEE: Copy

MAGED ABDEL GALIL HAMED, and AHMED FATHY ABDEL GHANY, “THE DIAGNOSTIC DIFFERENCE BETWEEN ¹⁸F- FDG PET AND ^99MTC-HMPAO SPECT PERFUSION IMAGING IN ASSESSMENT OF ALZHEIMER'S DISEASE,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 25, no. 1 (SERIAL NUMBER 47), pp. 17–22, 2017, [Online]. Available: https://sid.ir/paper/715186/en

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