مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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1

Information Journal Paper

Title

Protective effects of nimodipine and lithium against aluminum-induced cell death and oxidative stress in PC12 cells

Pages

  1251-1257

Abstract

 Objective(s): The role of Aluminum (Al) in the pathogenesis of neurodegenerative diseases has been implicated in several studies. However, the exact mechanisms of cytotoxic effects of Al have not been elucidated yet. The aim of this study was to investigate the effect of L-type calcium channel antagonist, Nimodipine (NM), and Lithium chloride (LiCl) on Al-induced toxicity in PC12 cells. Materials and Methods: PC12 cells were treated with Al-maltolate (Almal) in the presence and absence of different concentrations of NM (50-150 μ m) and/or LiCl (0. 5-1. 0 mM) for 48 hr. Cell viability, Apoptosis, and catalase (CAT) activity, a marker of oxidative stress, were then measured using MTT, flow cytometry and enzyme assay, respectively. Results: The results showed that Almal, dose dependently induced cell death, Apoptosis and CAT activity in the PC12 cells. NM significantly increased cell viability and decreased Apoptosis and CAT activity of Almal-treated cells in a dose dependent mode. LiCl reduced CAT activity and increased cell viability in Almal-treated cells, without significant effect on Apoptosis (P=0. 74). Conclusion: These findings suggest that NM and Li may have benefits in the prevention of Al-induced cytotoxicity through decreasing oxidative stress.

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    APA: Copy

    SABERZADEH, JAMILEH, Omrani, Mehdi, & TAKHSHID, MOHAMMAD ALI. (2016). Protective effects of nimodipine and lithium against aluminum-induced cell death and oxidative stress in PC12 cells. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(11), 1251-1257. SID. https://sid.ir/paper/723628/en

    Vancouver: Copy

    SABERZADEH JAMILEH, Omrani Mehdi, TAKHSHID MOHAMMAD ALI. Protective effects of nimodipine and lithium against aluminum-induced cell death and oxidative stress in PC12 cells. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(11):1251-1257. Available from: https://sid.ir/paper/723628/en

    IEEE: Copy

    JAMILEH SABERZADEH, Mehdi Omrani, and MOHAMMAD ALI TAKHSHID, “Protective effects of nimodipine and lithium against aluminum-induced cell death and oxidative stress in PC12 cells,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 11, pp. 1251–1257, 2016, [Online]. Available: https://sid.ir/paper/723628/en

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