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Information Journal Paper

Title

Impact of Genetic Variants in Estrogen Receptor-β Gene in the Etiology of Uterine Leiomyomas

Pages

  151-160

Abstract

 Background: Uterine Leiomyomas are steroid hormone dependent myometrial Neoplasms of female genital tract which appear after menarche and regress at menopause. The present study evaluated the role of ER-β gene polymorphisms (rs3020449 C/T, rs3020450 G/A, rs1271572 G/T, rs1256049 G/Aand rs4986938 G/A) in the etiology of disease. Methods: A total of 150 clinically, ultrasonographically evaluated uterine Leiomyoma patients and an equal number of individuals as controls were considered for the present study. Genotype analysis was carried out by TETRA Primer Amplification Refractory Mutation System– PCR for promoter polymorphisms and PCR-RFLP method was done for exonic polymorphisms followed by agarose gel electrophoresis. The strength of the association of ER-β gene polymorphisms between controls and patients were measured by appropriate statistical methods. Results: An increased frequency of T/T genotype and T allele of rs3020449, AA genotype and A allele of rs3020450, T/T genotype and T allele of rs1271572, AA genotype and A allele of rs1256049 and A/A genotype and A allele of rs4986938 was observed in cases when compared with controls. Conclusion: The study indicates that the ER-β gene polymorphisms may act as a major genetic regulator in the etiology of uterine Leiomyomas.

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    APA: Copy

    Bharathi, Chitroju, Anupama, Desamala, Pratibha, Nallari, & Venkateshwari, Anantapur. (2019). Impact of Genetic Variants in Estrogen Receptor-β Gene in the Etiology of Uterine Leiomyomas. JOURNAL OF REPRODUCTION AND INFERTILITY, 20(3), 151-160. SID. https://sid.ir/paper/725254/en

    Vancouver: Copy

    Bharathi Chitroju, Anupama Desamala, Pratibha Nallari, Venkateshwari Anantapur. Impact of Genetic Variants in Estrogen Receptor-β Gene in the Etiology of Uterine Leiomyomas. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2019;20(3):151-160. Available from: https://sid.ir/paper/725254/en

    IEEE: Copy

    Chitroju Bharathi, Desamala Anupama, Nallari Pratibha, and Anantapur Venkateshwari, “Impact of Genetic Variants in Estrogen Receptor-β Gene in the Etiology of Uterine Leiomyomas,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 20, no. 3, pp. 151–160, 2019, [Online]. Available: https://sid.ir/paper/725254/en

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