مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

217
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

164
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Iranian crack induces hepatic injury through mitogen-activated protein kinase pathway in the liver of Wistar rat

Pages

  1179-1185

Abstract

 Objective(s): Iranian Crack (IC) is a heroin-based substance manifesting various pathologic side effects. Herein, we aimed to investigate the mechanism of IC-induced liver injuries in Wistar rats. Materials and Methods: Twenty male Wistar rats were randomly divided into two groups: control, and IC (0. 9 mg/kg/day/IP, for 30 days). Mitochondrial reactive oxygen species (ROS) production was measured by DCF fluorescence staining. The expression of tumor necrosis factor-alpha (TNF-α ), interleukin 1β (IL-1β ), and phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) and c-Jun N-terminal kinase (c-JNK) were assessed by immunoblotting assay. The intensity of collagen fiber in the liver was also determined by Trichrome-Masson staining. Furthermore, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) activities were measured using colorimetric methods. Results: Our results showed that ROS production, p38 MAPK, c-JNK phosphorylation levels, and expression of TNF-α and IL-1β were significantly elevated in the liver tissue of IC group as compared to the control group. Moreover, collagen fiber and ALT activity were increased in the liver tissue of IC group compared to the control group. However, there was no statistically significant difference in the levels of ALP between two groups. In addition, there was a positive correlation between the intensity of collagen fiber and the ALT activity, and the levels of TNF-α and IL-1β and liver enzymes activities including ALP, ALT, and AST. Conclusion: Our findings revealed that IC-induced liver cells injury is partially mediated by MAPK stress kinases. Therefore, regular liver examination in substance abuse is strongly recommended.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Parvaresh Anbar, Aliasghar, Piran, Tayyebeh, Farhadi, Mehrdad, & KARIMI, POURAN. (2018). Iranian crack induces hepatic injury through mitogen-activated protein kinase pathway in the liver of Wistar rat. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(11), 1179-1185. SID. https://sid.ir/paper/726619/en

    Vancouver: Copy

    Parvaresh Anbar Aliasghar, Piran Tayyebeh, Farhadi Mehrdad, KARIMI POURAN. Iranian crack induces hepatic injury through mitogen-activated protein kinase pathway in the liver of Wistar rat. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(11):1179-1185. Available from: https://sid.ir/paper/726619/en

    IEEE: Copy

    Aliasghar Parvaresh Anbar, Tayyebeh Piran, Mehrdad Farhadi, and POURAN KARIMI, “Iranian crack induces hepatic injury through mitogen-activated protein kinase pathway in the liver of Wistar rat,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 11, pp. 1179–1185, 2018, [Online]. Available: https://sid.ir/paper/726619/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button