A COMPARISON OF HEMODYNAMIC EFFECTS OF MIDAZOLAM AND THIOPENTAL IN INDUCTION OF ANAESTHESIA

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ALIJANPOUR M.E.; RABIEI S.M.; MIRSHEKARI S.

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Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2000 | Volume:2 | Issue:2 (6) Page(s): 27-32

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Title

A COMPARISON OF HEMODYNAMIC EFFECTS OF MIDAZOLAM AND THIOPENTAL IN INDUCTION OF ANAESTHESIA

Author(s)

ALIJANPOUR M.E. | RABIEI S.M. | MIRSHEKARI S. | Issue Writer Certificate

Keywords

THIOPENTAL SODIUMQ2

MIDAZOLAMQ3

SYSTOLIC BLOOD PRESSUREQ4

DIASTOLIC BLOOD PRESSUREQ4

HEART RATEQ3

Abstract

OBJECTIVE: Although THIOPENTAL SODIUM (Nesdonal) is an almost ideal drug for induction of anesthesia, but it mostly cause hemodynamic changes such as hypotension. The objective of this study is to compare homodynamic effects of THIOPENTAL SODIUM and MIDAZOLAM (From Benzodiazepine family) in order to replace it with thiopental when necessary. METHODS:50 patients in AS.AI were divided into two groups (each group 25 persons) randomly subjects in both groups were administered with premeditation with an equal dose per patient's weight. In first group anesthesia was started with THIOPENTAL SODIUM 4-5 mg/kg with succinylcolin and in the second group with MIDAZOLAM 0.25-0.3 mg/kg with succinylcolin and intubations was done after a given time. HEART RATE and blood pressure were recorded for both groups at special times and data were compared with each other.FINDINGS: In this study pulse rate of %20 of patients who received THIOPENTAL SODIUM were increased to 20 beats/min. It was 12% for MIDAZOLAM group the changes (p=0.000)were meaningful. An increase of SYSTOLIC BLOOD PRESSURE more than 40 mmHg from base after intubations with THIOPENTAL SODIUM in %24 of persons (p =0.011) and 2 min after intubation in %20 persons (P =0.048) were meaningful. There were no such variations in MIDAZOLAM group. Data shows that any rise or fall in blood pressure and HEART RATE observed with THIOPENTAL SODIUM is more than that with MIDAZOLAM. CONCLUSION: Considering this research and the other studies show more record of homodynamic condition of MIDAZOLAM than THIOPENTAL SODIUM. Therefore, in patients with dangerous homodynamic variations, especially decreasing of blood pressure only induction with MIDAZOLAM or a combination of MIDAZOLAM and thiopental (for rapid onest action) as co-induction is useful.

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APA: Copy

ALIJANPOUR, M.E., RABIEI, S.M., & MIRSHEKARI, S.. (2000). A COMPARISON OF HEMODYNAMIC EFFECTS OF MIDAZOLAM AND THIOPENTAL IN INDUCTION OF ANAESTHESIA. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 2(2 (6)), 27-32. SID. https://sid.ir/paper/72912/en

Vancouver: Copy

ALIJANPOUR M.E., RABIEI S.M., MIRSHEKARI S.. A COMPARISON OF HEMODYNAMIC EFFECTS OF MIDAZOLAM AND THIOPENTAL IN INDUCTION OF ANAESTHESIA. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2000;2(2 (6)):27-32. Available from: https://sid.ir/paper/72912/en

IEEE: Copy

M.E. ALIJANPOUR, S.M. RABIEI, and S. MIRSHEKARI, “A COMPARISON OF HEMODYNAMIC EFFECTS OF MIDAZOLAM AND THIOPENTAL IN INDUCTION OF ANAESTHESIA,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 2, no. 2 (6), pp. 27–32, 2000, [Online]. Available: https://sid.ir/paper/72912/en

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