INFLUENCE OF MATERNAL NICOTINE EXPOSURE ON NEONATAL RAT KIDNEY STRUCTURE

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KARIMPOUR MALEKSHAH A.A.; TALEBPOUR AMIRI F.; TARINGOU F.; MASHAYEKHI Y.; EMADIAN O.

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Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2006 | Volume:8 | Issue:5 (33) Page(s): 13-19

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Title

INFLUENCE OF MATERNAL NICOTINE EXPOSURE ON NEONATAL RAT KIDNEY STRUCTURE

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Keywords

NICOTINEQ3

KIDNEY DEVELOPMENTQ3

RENAL CONGENITAL ANOMALYQ3

FETAL GROWTH RETARDATIONQ3

Abstract

BACKGROUND & OBJECTIVE: Cigarette smoke is composed of several compounds and the major one is the alkaloid NICOTINE. Few studies have assessed the teratogenic effects of prenatal NICOTINE exposure in some sensitive organs such as kidneys. The aim of this study was to determine the effects of maternal NICOTINE exposure during pregnancy on neonatal rat kidney structure.METHODS: Twenty four virgin female rats of 200-250g were used in this investigation. Pregnant dams were randomly divided into control and 3 experimental groups. The experimental groups received NICOTINE subcutaneously at dosages of 1, 3 and 6 mg/kg/day respectively throughout gestation for 20 days. The control animals received saline. After birth the pups were weighed, length measured and then killed by ether and the kidneys were quickly removed, weighed and fixed in bowann solution. The microscopic slides were examined histologically. Also the number of glomeruli per optical field covering the entire thickness of the cortex, the proportional volume density of corpuscles to cortex and cortex to medulla were determined.FINDINGS: The results show that maternal NICOTINE exposure results in (a) a decreased (p<0.05) body weight in dosage of 6mglkg and decreased (p<0.05) crown-rump length in dosages of 3 and 6mglkg (b), a decreased (p<0.05) kidneys weight in dosage of6mg/kg (c), and a decreased (p<0.0001) corpuscle count in all experimental groups.CONCLUSION: These data indicate that neonatal NICOTINE exposure. during pregnancy has a detrimental effect on general growth and a relatively low toxic effect on kidneys development.

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APA: Copy

KARIMPOUR MALEKSHAH, A.A., TALEBPOUR AMIRI, F., TARINGOU, F., MASHAYEKHI, Y., & EMADIAN, O.. (2006). INFLUENCE OF MATERNAL NICOTINE EXPOSURE ON NEONATAL RAT KIDNEY STRUCTURE. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 8(5 (33)), 13-19. SID. https://sid.ir/paper/73100/en

Vancouver: Copy

KARIMPOUR MALEKSHAH A.A., TALEBPOUR AMIRI F., TARINGOU F., MASHAYEKHI Y., EMADIAN O.. INFLUENCE OF MATERNAL NICOTINE EXPOSURE ON NEONATAL RAT KIDNEY STRUCTURE. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2006;8(5 (33)):13-19. Available from: https://sid.ir/paper/73100/en

IEEE: Copy

A.A. KARIMPOUR MALEKSHAH, F. TALEBPOUR AMIRI, F. TARINGOU, Y. MASHAYEKHI, and O. EMADIAN, “INFLUENCE OF MATERNAL NICOTINE EXPOSURE ON NEONATAL RAT KIDNEY STRUCTURE,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 8, no. 5 (33), pp. 13–19, 2006, [Online]. Available: https://sid.ir/paper/73100/en

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