EFFECT OF PISTACHIO RED PEEL EXTRACT ON MORPHINE WITHDRAWAL SIGNS IN MORPHINE DEPENDENT MALE RATS

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KALANTARIPOUR T.; MOBASHER M.; ASADI SHEKARI M.; RAFTARI SH.

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Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2007 | Volume:9 | Issue:1 (36) Page(s): 14-19

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Title

EFFECT OF PISTACHIO RED PEEL EXTRACT ON MORPHINE WITHDRAWAL SIGNS IN MORPHINE DEPENDENT MALE RATS

Author(s)

KALANTARIPOUR T. | MOBASHER M. | ASADI SHEKARI M. | RAFTARI SH. | Issue Writer Certificate

Keywords

RATQ2

MORPHINE WITHDRAWALQ3

PISTACHIO PEELQ2

Abstract

Background and objective: Pistachio is an edible Plant with several benefits in traditional medicine. Previous studies have shown that different parts of this plant have medical implication. There are antraquinone, tanin and flavonoids in PISTACHIO PEEL. This study was designed to assess the effect of red domestic PISTACHIO PEEL aqueous extract (PPAE) on decreasing MORPHINE WITHDRAWAL signs in male RATs.Methods: In this experimental study 176 male NMRI RATs weighting 200-250gr were selected. Animals were divided into 3 classes: a) acute injection of extract, b) acute gavage of extract, c) chronic gavage of extract. RATs were made dependent by adding various doses of morphine sulphate (0.1, 0.2 and 0.3 mg/ml each for 48 hours and 0.4 mg/ml during following days) to drinking water for 14 days.Findings: PPAE decreased the withdrawal signs. In comparison to the control group weight loss was significantly reduced at 50 mg/kg (p<0.05) and 100 mg/kg (p<0.000) doses of extract, head shake was significantly reduced at all doses of extract except at 50 mg/kg (at 12.5 mg/kg, p<0.01 and for other doses p<0.05) and wet dog shake significantly reduced at all doses except 6 and 50 mg/kg (at 12.5 and 400 mg/kg, p<0.001 and for other doses p<0.05). In acute gavage groups, extract only could decrease weight loss at 50 and 100 mg/kg in comparison to the saline group (at 50 mg/kg, p<0.01 and 100 mg/kg, p<0.01(.Conclusion: This study showed that ppae can reduce MORPHINE WITHDRAWAL signs, when perform in injecting form. As our extract contains whole components of PISTACHIO PEEL, so we don’t know which part is responsible for this effect. Complementary studies with the analysis of consistent are recommended for this purpose.

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APA: Copy

KALANTARIPOUR, T., MOBASHER, M., ASADI SHEKARI, M., & RAFTARI, SH.. (2007). EFFECT OF PISTACHIO RED PEEL EXTRACT ON MORPHINE WITHDRAWAL SIGNS IN MORPHINE DEPENDENT MALE RATS. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 9(1 (36)), 14-19. SID. https://sid.ir/paper/73189/en

Vancouver: Copy

KALANTARIPOUR T., MOBASHER M., ASADI SHEKARI M., RAFTARI SH.. EFFECT OF PISTACHIO RED PEEL EXTRACT ON MORPHINE WITHDRAWAL SIGNS IN MORPHINE DEPENDENT MALE RATS. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2007;9(1 (36)):14-19. Available from: https://sid.ir/paper/73189/en

IEEE: Copy

T. KALANTARIPOUR, M. MOBASHER, M. ASADI SHEKARI, and SH. RAFTARI, “EFFECT OF PISTACHIO RED PEEL EXTRACT ON MORPHINE WITHDRAWAL SIGNS IN MORPHINE DEPENDENT MALE RATS,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 9, no. 1 (36), pp. 14–19, 2007, [Online]. Available: https://sid.ir/paper/73189/en

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