Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

357
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

302
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Methylation Status of MTHFR Promoter and Oligozoospermia Risk: An Epigenetic Study and in Silico Analysis

Pages

  482-490

Abstract

 Objective: In this study, we evaluated the effects of promoter methylation of MTHFR on Oligozoospermia risk, followed by an in silico analysis. Materials and Methods: In a case-control study, semen samples were collected from infertile and healthy control men. MTHFR promoter region was amplified by methylation-specific polymerase chain reaction (PCR). Finally, the promoter region of MTHFR was analyzed by Bioinformatics software. Results: Our data revealed significant associations of CpG island promoter methylation with Oligozoospermia in a case-control study. In silico analysis showed that promoter contains a strong nucleosome exclusion region, a bonafide CGIs, six PROSITE motifs without a defined TATA box and 14 transcription factor (TF) binding sites, which are directly involved in spermatogenesis Conclusion: Based on our findings, methylation of the MTHFR gene promoter region may be a risk factor for Oligozoospermia. However, this is a preliminary report representing data for future comprehensive studies to make a clinical conclusion on the potential biomarker role of methylation of this promoter in elevating susceptibility to Oligozoospermia.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Rezaeian, Atefeh, KARIMIAN, MOHAMMAD, & HOSSIENZADEH COLAGAR, ABASALT. (2021). Methylation Status of MTHFR Promoter and Oligozoospermia Risk: An Epigenetic Study and in Silico Analysis. CELL JOURNAL (YAKHTEH), 22(4 (88)), 482-490. SID. https://sid.ir/paper/735604/en

    Vancouver: Copy

    Rezaeian Atefeh, KARIMIAN MOHAMMAD, HOSSIENZADEH COLAGAR ABASALT. Methylation Status of MTHFR Promoter and Oligozoospermia Risk: An Epigenetic Study and in Silico Analysis. CELL JOURNAL (YAKHTEH)[Internet]. 2021;22(4 (88)):482-490. Available from: https://sid.ir/paper/735604/en

    IEEE: Copy

    Atefeh Rezaeian, MOHAMMAD KARIMIAN, and ABASALT HOSSIENZADEH COLAGAR, “Methylation Status of MTHFR Promoter and Oligozoospermia Risk: An Epigenetic Study and in Silico Analysis,” CELL JOURNAL (YAKHTEH), vol. 22, no. 4 (88), pp. 482–490, 2021, [Online]. Available: https://sid.ir/paper/735604/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top