THE RESPONSE TO HEPATITIS B VIRUS VACCINE IN HIV-INFECTED PATIENTS (HIV/AIDS COUNSELLING AND CARE CENTER IN KERMANSHAH)

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ALAEI K.; MANSOURI D.; ALAEI A.

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Paper Information

Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2004 | Volume:6 | Issue:2 (22) Page(s): 46-51

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Title

THE RESPONSE TO HEPATITIS B VIRUS VACCINE IN HIV-INFECTED PATIENTS (HIV/AIDS COUNSELLING AND CARE CENTER IN KERMANSHAH)

Author(s)

ALAEI K. | MANSOURI D. | ALAEI A. | Issue Writer Certificate

Keywords

HIV/AIDSQ3

HEPATITIS B VACCINEQ3

CD4+T LYMPHOCYTESQ4

Abstract

BACKGROUND AND OBJECTIVE: HBV infection is preventable by effective vaccination in general population, but response to vaccine among HIV infected people seems to be low. METHODS: In this prospective study, 48 HIV positive patients with anti Hbs-Ab and Hbs Ag had hepatitis B vaccination (0, 1, 6 months). Anti-Hbs levels were measured two months after the last dose by Elisa method. Cellular immunity was evaluated by flocytometry. FINDINGS: Only 14 (29.1%) of vaccinated HIV-infected patients had positive anti-HBs titers (11 males, 3 females). Among them, 4 (28.6%) were over 40 years and from 34 HIV positive patients who did not respond to HEPATITIS B VACCINE, 10 (29.4%) were over 40 years old. The mean number of CD4+ T lymphocytes was 352.5 in responders and 283.9 in nonresponders. Two (17.6%) of 17 HIV positive patients with CDT4<200 and 6 (31.5%) of 19 HIV positive patients with 200<CD4< 500 and 3 (42.8%) of 7 HIV positive with CD4>500 responded to HEPATITIS B VACCINE. CONCLUSION: Hepatitis B vaccination is better to be administered at the early stage of HIV infection. Conventional dose HIV vaccine is not enough for immunity. Therefore, it is recommended two-fold dose and repeated conventional dose or increasing interval administration of HEPATITIS B VACCINE.

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RESPONSE TO HEPATITIS B VACCINE IN HIV-INFECTED PATIENTS

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APA: Copy

ALAEI, K., MANSOURI, D., & ALAEI, A.. (2004). THE RESPONSE TO HEPATITIS B VIRUS VACCINE IN HIV-INFECTED PATIENTS (HIV/AIDS COUNSELLING AND CARE CENTER IN KERMANSHAH) . JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 6(2 (22)), 46-51. SID. https://sid.ir/paper/73591/en

Vancouver: Copy

ALAEI K., MANSOURI D., ALAEI A.. THE RESPONSE TO HEPATITIS B VIRUS VACCINE IN HIV-INFECTED PATIENTS (HIV/AIDS COUNSELLING AND CARE CENTER IN KERMANSHAH) . JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2004;6(2 (22)):46-51. Available from: https://sid.ir/paper/73591/en

IEEE: Copy

K. ALAEI, D. MANSOURI, and A. ALAEI, “THE RESPONSE TO HEPATITIS B VIRUS VACCINE IN HIV-INFECTED PATIENTS (HIV/AIDS COUNSELLING AND CARE CENTER IN KERMANSHAH) ,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 6, no. 2 (22), pp. 46–51, 2004, [Online]. Available: https://sid.ir/paper/73591/en

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