THE EFFECT OF HYDROALCOHOLIC EXTRACT OF ACHILLEA MILLEFOLIUM ON NALGESIC EFFECT OF MORPHINE IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ARZI A.; AKHAVAN M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2001 | Volume:3 | Issue:4 (12) Page(s): 11-14

Download Full-Text

Persian Verion

View:

1,372

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF HYDROALCOHOLIC EXTRACT OF ACHILLEA MILLEFOLIUM ON NALGESIC EFFECT OF MORPHINE IN RATS

Author(s)

ARZI A. | AKHAVAN M. | Issue Writer Certificate

Keywords

ACHILLEA MILLEFOLIUMQ2

MORPHINEQ2

PAINQ2

RATQ2

Abstract

OBJECTIVE: ACHILLEA MILLEFOLIUM is a plant whose anti-inflammatory effects were proved by inhibition of cyclooxygenase enzyme activities. In this study, the effect of its hydroalcoholic extract on analgesic effect of MORPHINE was investigated to lower the dose of injected MORPHINE as much as possible. METHODS: This study was performed on RATs by tail flick test. At first a suitable dose of MORPHINE that caused analgesia was selected by dose response method. Then analgesic effect of different doses of ACHILLEA MILLEFOLIUM extract (25, 50, 75 and 100mg/kg) and also the effect of these doses on analgesic effect of a suitable dose of MORPHINE (2.5mg/kg) were investigated. FINDINGS: According to the results and by using analytical variance method, the best dose of extract selected for improving the analgesic effect of MORPHINE was 75mg/kg (p<0.05). Reflex time in control group to algogenic stimulant was about 2-3 seconds and in RATs which received different doses of hydroalcoholic extract of ACHILLEA MILLEFOLIUM before injection of MORPHINE (2.5 mg/kg) in comparison to those which only received MORPHINE showed a significant increase (p<0.05). CONCLUSION: All doses of hydroalcoholic extract of ACHILLEA MILLEFOLIUM caused an increase of analgesic effect of MORPHINE significantly (p<0.05). Meanwhile, the strongest effect was observed at 45 th minute of the trial.

Cites

References

No record.

Cite

APA: Copy

ARZI, A., & AKHAVAN, M.. (2001). THE EFFECT OF HYDROALCOHOLIC EXTRACT OF ACHILLEA MILLEFOLIUM ON NALGESIC EFFECT OF MORPHINE IN RATS. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 3(4 (12)), 11-14. SID. https://sid.ir/paper/73734/en

Vancouver: Copy

ARZI A., AKHAVAN M.. THE EFFECT OF HYDROALCOHOLIC EXTRACT OF ACHILLEA MILLEFOLIUM ON NALGESIC EFFECT OF MORPHINE IN RATS. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2001;3(4 (12)):11-14. Available from: https://sid.ir/paper/73734/en

IEEE: Copy

A. ARZI, and M. AKHAVAN, “THE EFFECT OF HYDROALCOHOLIC EXTRACT OF ACHILLEA MILLEFOLIUM ON NALGESIC EFFECT OF MORPHINE IN RATS,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 3, no. 4 (12), pp. 11–14, 2001, [Online]. Available: https://sid.ir/paper/73734/en

Related Journal Papers