HYPOGLYCEMIC EFFECTS OF ACHILLEA WILHELMSII IN NORMAL AND STREPTOZOTOCIN INDUCED DIABETIC RATS

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SADEGHI H.A.; RADMANESH E.; AKBAR TABAR TOURI M.; MOHAMMADI REZA; NAZEM H.A.

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Journal: Armaghane Danesh Year:2009 | Volume:14 | Issue:1 (53) Page(s): 91-99

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Title

HYPOGLYCEMIC EFFECTS OF ACHILLEA WILHELMSII IN NORMAL AND STREPTOZOTOCIN INDUCED DIABETIC RATS

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Keywords

DIABETESQ2

ACHILEA WILHELMSIIQ2

BLOOD GLUCOSEQ3

STREPTOZOTOCINQ2

Abstract

Introduction & Objective: DIABETES mellitus is a syndrome, initially characterized by a loss of glucose homeostasis resulting from defects in Insulin secretion, insulin action both is resulting in impaired metabolism of glucose and other energy yielding fuels as lipids and protein. Several medicinal herbs have been described with hypoglycemic effects. These include: Allium Sativum, Trigonella Foenum, Marus nigra, Ocimum Sanctum, and Astragalus Ovinus. The main purpose of the present study was to determine the effect of Achillea Wilhelmsii C. Koch on BLOOD GLUCOSE levels of diabetic rats induced by stereptozotocine (STZ).Materials & Methods: In this experimental research, forty-eight male Wistar rats were divided into two groups: non-diabetic (normal) and STZ-induced diabetic mice. Each group was further divided into four groups: control (induced by normal saline) and treatment received 100, 200.and 300 mg/kg aqueous- alcoholic extract of Achillea Wilhelmsii C. Koch daily for one month. The BLOOD GLUCOSE level was measured and Data were analyzed by ttest and ANOVA.Results: At the end of first month, significant decrease was observed in BLOOD GLUCOSE level in diabetic rats which received 100 mg/kg (p<0/001), 200mg/kg (p<0/01), 300mg/kg (p<0/001) of aqueous alcoholic extract of Achillea Wilhelmsii C. Koch in comparison with control groups. The extract had not have any significant effects on the BLOOD GLUCOSE level of normal groups except in those which received 300mg/kg of the extract. Conclusion: The results of this study showed that aqueousalcoholic extract of Achillea Wilhelmsii C. Koch have a significant effect on reducing the BLOOD GLUCOSE level of diabetic rats.

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APA: Copy

SADEGHI, H.A., RADMANESH, E., AKBAR TABAR TOURI, M., MOHAMMADI, REZA, & NAZEM, H.A.. (2009). HYPOGLYCEMIC EFFECTS OF ACHILLEA WILHELMSII IN NORMAL AND STREPTOZOTOCIN INDUCED DIABETIC RATS. ARMAGHAN DANESH, 14(1 (53)), 91-99. SID. https://sid.ir/paper/77985/en

Vancouver: Copy

SADEGHI H.A., RADMANESH E., AKBAR TABAR TOURI M., MOHAMMADI REZA, NAZEM H.A.. HYPOGLYCEMIC EFFECTS OF ACHILLEA WILHELMSII IN NORMAL AND STREPTOZOTOCIN INDUCED DIABETIC RATS. ARMAGHAN DANESH[Internet]. 2009;14(1 (53)):91-99. Available from: https://sid.ir/paper/77985/en

IEEE: Copy

H.A. SADEGHI, E. RADMANESH, M. AKBAR TABAR TOURI, REZA MOHAMMADI, and H.A. NAZEM, “HYPOGLYCEMIC EFFECTS OF ACHILLEA WILHELMSII IN NORMAL AND STREPTOZOTOCIN INDUCED DIABETIC RATS,” ARMAGHAN DANESH, vol. 14, no. 1 (53), pp. 91–99, 2009, [Online]. Available: https://sid.ir/paper/77985/en

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