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Information Journal Paper

Title

Prediction of Gestational Diabetes by Measuring the Levels of Pregnancy Associated Plasma Protein-A (PAPP-A) During Gestation Weeks 11-14

Pages

  130-137

Abstract

 Background: The present study aimed to determine the association between pregnancy-associated plasma protein A (PAPP-A) and Gestational diabetes Methods (GDM) to detect a risk factor for predicting GDM at gestational weeks 11-14. Methods: This analytical prospective study recruited 284 pregnant women presenting to six healthcare centers of Qazvin, Iran from February to December 2016. PAPP-A was measured at gestational weeks 11-14 and glucose tolerance test was conducted at gestational weeks 24-28. The participants were assigned into two groups of exposure (reduced PAPP-A) and non-exposure (normal PAPP-A). The association between GDM and PAPP-A was studied. The number of women in exposure group were 201 and 83 in the non-exposure group. Differences between groups were assessed by the Mann– Whitney, Chi-square, T test, logistic regression analysis and ROC Curve with a significance level of 0. 05. Results: Twenty eight (33. 73%) patients of the exposure group and 17 (8. 46%) of non-exposure group developed GDM. There was a significant difference between the two groups in terms of GDM (p<0. 001) and the risk of GDM was 3. 98 fold higher in the exposure group (reduced PAPPA mu/L) than that of the non-exposure group (CI=2. 39-6. 65, p<0. 001). Also, 53. 3% of the exposure group and 46. 7% of the nonexposure group were diagnosed with GDM (p=0. 02). There was a significant difference in GDM between the groups and the risk of GDM was 1. 85 times higher in the exposure group (reduced PAPPA MOM) than that in the control group (CI=1. 09-3. 15, p=0. 020). According to the ROC curve results, PAPP-A and MOM are acceptable indicators for predicting GDM. Conclusion: A low PAPP-A level (MOM, MU/L) as a new risk factor for GDM can help early prediction and prevent maternal and fetal complication by timely treatment.

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    APA: Copy

    RAMEZANI, SOMAYEH, AHMADI DOULABI, MAHBOBEH, SAQHAFI, HAMID, & ALIPOOR, MAHMOOD. (2020). Prediction of Gestational Diabetes by Measuring the Levels of Pregnancy Associated Plasma Protein-A (PAPP-A) During Gestation Weeks 11-14. JOURNAL OF REPRODUCTION AND INFERTILITY, 21(2), 130-137. SID. https://sid.ir/paper/741419/en

    Vancouver: Copy

    RAMEZANI SOMAYEH, AHMADI DOULABI MAHBOBEH, SAQHAFI HAMID, ALIPOOR MAHMOOD. Prediction of Gestational Diabetes by Measuring the Levels of Pregnancy Associated Plasma Protein-A (PAPP-A) During Gestation Weeks 11-14. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2020;21(2):130-137. Available from: https://sid.ir/paper/741419/en

    IEEE: Copy

    SOMAYEH RAMEZANI, MAHBOBEH AHMADI DOULABI, HAMID SAQHAFI, and MAHMOOD ALIPOOR, “Prediction of Gestational Diabetes by Measuring the Levels of Pregnancy Associated Plasma Protein-A (PAPP-A) During Gestation Weeks 11-14,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 21, no. 2, pp. 130–137, 2020, [Online]. Available: https://sid.ir/paper/741419/en

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