Sub-threshold electrical stimulation improves winglesstype3 and eukaryotic initiation factor-2α expression in the presence of exogenous astrocyte in the rat model of spinal cord injury

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GHORBANI MEYSAM; SHAHABI PARVIZ; KARIMI POURAN; JAVAN MOHAMMAD; BANI SOHEILA; HOSSEINI SABA; Soltani Zangbar Hamid; SADEGHZADEH OSKOUEI BEHNAZ

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Journal: Physiology and Pharmacology Year:2020 | Volume:24 | Issue:1 Page(s): 34-45

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Title

Sub-threshold electrical stimulation improves winglesstype3 and eukaryotic initiation factor-2α expression in the presence of exogenous astrocyte in the rat model of spinal cord injury

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Keywords

Spinal cord injury

Electrical stimulation

GFAP

Doublecortin

Wingless-type3

Abstract

Introduction: Spinal cord injury (SCI) is a condition which can lead to permanent loss of neurons, glial and precursor cells. According to the positive influences of Electrical stimulation in the neurogenesis, we hypothesized that sub-threshold Electrical stimulation in the presence of exogenous astrocyte may trigger the differential regulation of Wingless-type3 (Wnt-3) and eukaryotic initiation factor-2α (eIF2α ) mediators in spinal cord injured rats. Methods: Forty male Wistar rats (weighing 250-280g) were randomly divided into four groups: sham, SCI, SCI+astrocyte and SCI+astrocyte which followed by Electrical stimulation. We evaluated the glial fibrillary acidic protein (GFAP), Doublecortin, Wnt-3 and eIF2α proteins by immunofluorescence and immunoblotting techniques. Results: The results show that expression of Wnt-3 and eIF2α proteins significantly enhanced after 14 days in the Electrical stimulation+ SCI+astrocyte group in comparison with SCI and SCI+astrocyte groups. Also, the expression of GFAP cells was significantly increased after 14 days by Electrical stimulation compared with other groups. Electrical stimulation had no effect on expression of Doublecortin after 14 days. Conclusion: This survey demonstrates that sub-threshold Electrical stimulation upregulates Wnt-3 and eIF2α mediators. Also, GFAP marker expression has been increased in animals subjected to Electrical stimulation. But there are no evidences based on Doublecortin expression as a neurogenesis biomarker.

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APA: Copy

GHORBANI, MEYSAM, SHAHABI, PARVIZ, KARIMI, POURAN, JAVAN, MOHAMMAD, BANI, SOHEILA, HOSSEINI, SABA, Soltani Zangbar, Hamid, & SADEGHZADEH OSKOUEI, BEHNAZ. (2020). Sub-threshold electrical stimulation improves winglesstype3 and eukaryotic initiation factor-2α expression in the presence of exogenous astrocyte in the rat model of spinal cord injury. PHYSIOLOGY AND PHARMACOLOGY, 24(1), 34-45. SID. https://sid.ir/paper/742326/en

Vancouver: Copy

GHORBANI MEYSAM, SHAHABI PARVIZ, KARIMI POURAN, JAVAN MOHAMMAD, BANI SOHEILA, HOSSEINI SABA, Soltani Zangbar Hamid, SADEGHZADEH OSKOUEI BEHNAZ. Sub-threshold electrical stimulation improves winglesstype3 and eukaryotic initiation factor-2α expression in the presence of exogenous astrocyte in the rat model of spinal cord injury. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2020;24(1):34-45. Available from: https://sid.ir/paper/742326/en

IEEE: Copy

MEYSAM GHORBANI, PARVIZ SHAHABI, POURAN KARIMI, MOHAMMAD JAVAN, SOHEILA BANI, SABA HOSSEINI, Hamid Soltani Zangbar, and BEHNAZ SADEGHZADEH OSKOUEI, “Sub-threshold electrical stimulation improves winglesstype3 and eukaryotic initiation factor-2α expression in the presence of exogenous astrocyte in the rat model of spinal cord injury,” PHYSIOLOGY AND PHARMACOLOGY, vol. 24, no. 1, pp. 34–45, 2020, [Online]. Available: https://sid.ir/paper/742326/en

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