VALUATION OF ORIGANUM VULGARE (LEAVES, STEMS AND FLOWERS) EXTRACT ON SPATIAL LEARNING IN MALE RATS

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ABBASNEZHAD M.; MIRTAJ ALDINI S.M.; HASIBI N.; AFARINESH M.R.

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Journal: Physiology and Pharmacology Year:2006 | Volume:10 | Issue:2 Page(s): 143-150

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Title

VALUATION OF ORIGANUM VULGARE (LEAVES, STEMS AND FLOWERS) EXTRACT ON SPATIAL LEARNING IN MALE RATS

Author(s)

ABBASNEZHAD M. | MIRTAJ ALDINI S.M. | HASIBI N. | AFARINESH M.R. | Issue Writer Certificate

Keywords

MEDICINAL PLANTQ3

ORIGANUM VULGAREQ3

SPATIAL LEARNINGQ4

T-MAZEQ4

Abstract

Introduction: ORIGANUM VULGARE a rich source of natural phenolic antioxidants and has potential to be a source of nutritional ingredients for functional food. Herbs such as Origanum have long been used in food preservation and in traditional medicine in the treatment of common ailments and have potential for positive modulation of oxidation-linked diseases such as diabetes. Here we investigated the effect of aqueous extract of Origanum (leaves, stems and flowers) on SPATIAL LEARNING.Methods: After scientific identification, the leaves were used for extraction. 35 adult NMRI male rats weighing 250-350 gr were utilized in 5 groups. Control group (no injection), the second group (saline injected), the extracts with different doses (150, 300, 450) mg/kg were injected intraperitoneally to experimental animals. All animals were trained for a SPATIAL LEARNING task using T-MAZE and were then trained subsequently daily based on standard method.Results: Statistic analysis ANOVA showed that Origanum aqueous extract significantly decreased the number of learning and error in simple and reverse learning (p<0.05) and it had no significant effect on delay time in both type of learning.Conclusion: It can be concluded that the effect of Origanum extract on learning can be due to its antioxidant and presence of anti acetylcholine estrase compounds such as ursolic acid.

Cites

STUDY OF ANXIOLYTIC EFFECT OF HERBAL EXTRACT OF ORIGANUM MAJORANA L. INCOMPARISON WITH DIAZEPAM IN RAT

References

THE EFFECT OF CO ADMINISTRATION OF LECITHIN (LC) AND RETINOIC ACID (RA) ON SPATIAL LEARNING IN ADULT MALE RATS (NMRI) IN T-MAZE APPARATUS

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APA: Copy

ABBASNEZHAD, M., MIRTAJ ALDINI, S.M., HASIBI, N., & AFARINESH, M.R.. (2006). VALUATION OF ORIGANUM VULGARE (LEAVES, STEMS AND FLOWERS) EXTRACT ON SPATIAL LEARNING IN MALE RATS. PHYSIOLOGY AND PHARMACOLOGY, 10(2), 143-150. SID. https://sid.ir/paper/74895/en

Vancouver: Copy

ABBASNEZHAD M., MIRTAJ ALDINI S.M., HASIBI N., AFARINESH M.R.. VALUATION OF ORIGANUM VULGARE (LEAVES, STEMS AND FLOWERS) EXTRACT ON SPATIAL LEARNING IN MALE RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2006;10(2):143-150. Available from: https://sid.ir/paper/74895/en

IEEE: Copy

M. ABBASNEZHAD, S.M. MIRTAJ ALDINI, N. HASIBI, and M.R. AFARINESH, “VALUATION OF ORIGANUM VULGARE (LEAVES, STEMS AND FLOWERS) EXTRACT ON SPATIAL LEARNING IN MALE RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 10, no. 2, pp. 143–150, 2006, [Online]. Available: https://sid.ir/paper/74895/en

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