THE ROLE OF ADENOSINE AT RECEPTORS IN POST SEIZURE DEPRESSION PERIOD IN RATS

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ZEYNALI T.; MIRNAJAFIZADEH S.J.; SHEYBANI VAHID; ABBASNEZHAD MAHDI; PALIZVAN M.R.

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Journal: Physiology and Pharmacology Year:2007 | Volume:11 | Issue:3 Page(s): 174-181

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Title

THE ROLE OF ADENOSINE AT RECEPTORS IN POST SEIZURE DEPRESSION PERIOD IN RATS

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Keywords

EPILEPSYQ3

KINDLINGQ3

POST SEIZURE SUPPRESSIONQ3

ADENOSINEQ3

Abstract

Introduction: EPILEPSY is among the most common disorders of the central nervous system and there is not an absolute method for its treatment. It has been shown that each seizure has a depressing effect on the following seizure.Thus, finding the mechanisms responsible in this phenomenon can improve our knowledge toward new ways for EPILEPSY treatment. In this study, the role of ADENOSINE AI receptors in post seizure depressing period was investigated in amygdale KINDLING model of EPILEPSY.Methods: Rats were kindled by daily electrical stimulation of amygdale. At first, different groups of kindled animals were stimulated at different times after the first stimulation and the percent of suppression of seizure parameters were calculated. Then, 8-cyclopenthyl-l, 3-dimethylxanthine (CPT), a selective ADENOSINE AI receptor antagonist (50 and 200 mM) were intracerebroventriculady microinjected before the second stimulation and its effect on percent of suppression induced by the first stimulation was investigated.Results: In the second stimulation, applied at 10 and 30 min after the first stimulation, the seizure parameters were significantly reduced. CPT microinjection (50 and 200 mM) significantly decreased the percent of suppression of seizure parameters. This decrease was significant at 10 and 30 min after the first stimulation with compare to the groups received the drug solvent.Conclusion: Obtained results showed that endogenous ADENOSINE has a role in post seizure depression period through Al receptors. As the blocking of AI receptors by CPT could not completely prevent this period, other factors may also play role in this suppression.

Cites

THE ROLE OF GABAA RECEPTOR ACTIVITY IN POST-ICTAL DEPRESSION PERIOD IN A RAT KINDLING MODEL OF EPILEPSY

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APA: Copy

ZEYNALI, T., MIRNAJAFIZADEH, S.J., SHEYBANI, VAHID, ABBASNEZHAD, MAHDI, & PALIZVAN, M.R.. (2007). THE ROLE OF ADENOSINE AT RECEPTORS IN POST SEIZURE DEPRESSION PERIOD IN RATS. PHYSIOLOGY AND PHARMACOLOGY, 11(3), 174-181. SID. https://sid.ir/paper/74955/en

Vancouver: Copy

ZEYNALI T., MIRNAJAFIZADEH S.J., SHEYBANI VAHID, ABBASNEZHAD MAHDI, PALIZVAN M.R.. THE ROLE OF ADENOSINE AT RECEPTORS IN POST SEIZURE DEPRESSION PERIOD IN RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2007;11(3):174-181. Available from: https://sid.ir/paper/74955/en

IEEE: Copy

T. ZEYNALI, S.J. MIRNAJAFIZADEH, VAHID SHEYBANI, MAHDI ABBASNEZHAD, and M.R. PALIZVAN, “THE ROLE OF ADENOSINE AT RECEPTORS IN POST SEIZURE DEPRESSION PERIOD IN RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 11, no. 3, pp. 174–181, 2007, [Online]. Available: https://sid.ir/paper/74955/en

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